- ►diabetesjournals.org Z Wang, T Zhu, KK Rehman, S Bertera, J … - Diabetes, 2006 - Am Diabetes Assoc Diabetes is a disease of epidemic proportions and is on the rise worldwide. Gene
therapy has been actively pursued but limited by technical hurdles and profound
inefficiency of direct gene transfer to the pancreas in vivo. Here, we show ... Cited by 26 - Related articles - BL Direct - All 6 versions
KK Rehman, Z Wang, R Bottino, AN … - Gene Therapy, 2005 - nature.com Transplantation of allogeneic pancreatic islets is an effective approach to
treat type 1 diabetes. To bypass the need for systemic administration of
immunosuppression drugs following transplantation, approaches to ... Cited by 17 - Related articles - BL Direct - All 4 versions
SA Loiler, Q Tang, T Clarke, ML Campbell- … - Molecular Therapy, 2005 - Elsevier Gene transfer into pancreatic cells in vivo could be of immense therapeutic
benefit in cases of type 1 diabetes (T1D) through the production of molecules
capable of interrupting the progression of autoimmunity or promoting ... Cited by 16 - Related articles - All 5 versions
E Ayuso, M Chillón, F García, J Agudo, A … - Molecular Therapy, 2006 - Elsevier Gene therapy may provide new treatments for severe pancreatic disorders.
However, gene transfer to the pancreas is difficult because of its anatomic
location and structure, and pancreatitis is a serious concern. Like the ... Cited by 6 - Related articles - All 4 versions
JC Grieger, VW Choi, RJ Samulski - Nature Protocols, 2006 - nature.com The adeno-associated virus (AAV) is one of the most promising viral vectors for
human gene therapy. As with any potential therapeutic system, a thorough
understanding of it at the in vitro and in vivo levels is required. Over ... Cited by 21 - Related articles - BL Direct - All 3 versions
SJ McClane, N Chirmule, CV Burke, SE … - Human gene therapy, 1997 - liebertonline.com The pancreas is an ideal organ for adenoviral gene therapy because of the high
level of gene transfer that can be achieved and because of the many diseases
that can potentially be treated using this technology. In this re- port, ... Cited by 33 - Related articles - BL Direct - All 3 versions
L Gigout, P Rebollo, N Clement, KH … - Molecular Therapy, 2005 - Elsevier Over the past decade, AAV-based vectors have emerged as promising candidates for
gene therapeutic applications. Despite the broad tropism of the first eight
serotypes identified, certain cell types are refractory to transduction ... Cited by 25 - Related articles - All 4 versions
- ►nih.gov D Grimm, K Pandey, H Nakai, TA Storm, MA … - Journal of virology, 2006 - Am Soc Microbiol We and others have recently reported highly efficient liver gene transfer with
adeno-associated virus 8 (AAV-8) pseudotypes, ie, AAV-2 genomes packaged into
AAV-8 capsids. Here we studied whether liver transduction could be further ... Cited by 28 - Related articles - BL Direct - All 13 versions
