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Scholar Results 1 - 10 of about 101 related to Park: Accelerated diabetic nephropathy in mice lacking the Peroxisome Proliferator–Activated.... (0.10 sec) 

Accelerated diabetic nephropathy in mice lacking the Peroxisome Proliferator– …

- diabetesjournals.org
CW Park, HW Kim, SH Ko, HW Chung, SW Lim, CW … - Diabetes, 2006 - Am Diabetes Assoc
Peroxisome proliferator–activated receptor (PPAR)α, a member of the ligand-activated nuclear
receptor superfamily, plays an important role in lipid metabolism and glucose homeostasis and
is highly expressed in the kidney. The present studies were aimed at determining the role ...
Cited by 34 - Related articles - BL Direct - All 6 versions

PPARα agonist fenofibrate improves diabetic nephropathy in db/db mice


CW Park, Y Zhang, X Zhang, J Wu, L Chen, DR Cha, … - Kidney International, 2006 - nature.com
Peroxisome proliferator-activated receptor (PPAR ) is a member of the ligand-activated nuclear
receptor superfamily, and plays an important role in lipid metabolism and glucose
homeostasis. The purpose of this study is to determine whether the activation of PPAR by ...
Cited by 40 - Related articles - BL Direct - All 3 versions

The PPARα ligand fenofibrate: meeting multiple targets in diabetic nephropathy


Z Varghese, JF Moorhead, XZ Ruan - Kidney International, 2006 - nature.com
Fibrate peroxisome proliferator-activated receptor (PPAR)- ligands are mainly used as hypolipidemic
drugs. But this commentary highlights their potential in treating insulin resistance,
dyslipidemia, and hypertension and in preventing diabetic nephropathy, inflammation, ...
Cited by 9 - Related articles - BL Direct - All 3 versions

PPAR-{alpha} and-{gamma} agonists attenuate diabetic kidney disease in the …

- oxfordjournals.org
AC Calkin, S Giunti, KA Jandeleit-Dahm, TJ Allen, … - Nephrology Dialysis …, 2006 - ERA-EDTA
Backgound. Peroxisome proliferator-activated receptor (PPAR)- and PPAR- agonists are widely
used in diabetes. In addition to their effects on lipid and glucose homeostasis, these agents have
been postulated to have independent renoprotective actions. In the current study, we ...
Cited by 27 - Related articles - BL Direct - All 6 versions

Thiazolidinediones ameliorate diabetic nephropathy via cell cycle–dependent …


T Okada, J Wada, K Hida, J Eguchi, I Hashimoto, M … - Diabetes, 2006 - Am Diabetes Assoc
Thiazolidinediones are ligands for peroxisome proliferator–activated receptor (PPAR)-γ, widely
used as insulin sensitizer in type 2 diabetic patients and implicated in apoptosis, cell
proliferation, and cell cycle regulation. Here, the effect of thiazolidinediones on G1-phase ...
Cited by 25 - Related articles - BL Direct - All 5 versions

Pioglitazone attenuates diabetic nephropathy through an anti-inflammatory …

- oxfordjournals.org
GJ Ko, YS Kang, SY Han, MH Lee, HK Song, KH … - Nephrology Dialysis …, 2008 - ERA-EDTA
Results. Treatment of OLETF rats with pioglitazone improved insulin sensitivity and kidney/body
weight, but had a little effect on blood pressure. Pioglitazone treatment markedly reduced urinary
albumin and MCP-1 excretion, and ameliorated glomerulosclerosis. In cDNA microarray ...
Cited by 14 - Related articles - All 4 versions

PPAR-{alpha} activator fenofibrate increases renal CYP-derived eicosanoid …

- physiology.org
X Zhao, JE Quigley, J Yuan, MH Wang, Y … - American Journal of …, 2006 - Am Physiological Soc
Previous studies have shown that the synthesis of renal cytochrome P-450 (CYP)-derived eicosanoids
is downregulated in genetic or high-fat diet-induced obese rats. Experiments were designed
to determine whether fenofibrate, a peroxisome proliferator-activated receptor (PPAR)- ...
Cited by 16 - Related articles - BL Direct - All 3 versions

PPAR-α ligands inhibit H2O2-mediated activation of transforming growth factor-β1 …


WA Wilmer, CL Dixon, C Hebert, L Lu, BH … - Antioxidants and Redox …, 2002 - liebertonline.com
INTRODUCTION G LOMERULOSCLEROSIS is a final histologic feature of most
glomerulopathies, including those glomerular in- juries associated with systemic diseases such
as diabetes and hypertension. Resident cells within the glomerulus contribute to the ...
Cited by 15 - Related articles - BL Direct - All 4 versions

Peroxisome Proliferator–Activated Receptor α/γ Dual Agonist Tesaglitazar …


DR Cha, X Zhang, Y Zhang, J Wu, D Su, JY Han, X … - Diabetes, 2007 - Am Diabetes Assoc
Peroxisome proliferator–activated receptors (PPARs) are nuclear transcription factors and play
a central role in insulin sensitivity, lipid metabolism, and inflammation. Both PPARα and -γ are
expressed in the kidney, and their agonists exhibit renoprotective effects in type 2 ...
Cited by 17 - Related articles - BL Direct - All 4 versions

PPAR {gamma} agonists exert antifibrotic effects in renal tubular cells exposed to …

- physiology.org [PDF] 
… , S Sumual, CA Pollock, X Chen - American Journal of …, 2005 - Am Physiological Soc
37 articles, 15 of which you can access free at: This article cites http://ajprenal.physiology.org
/cgi/content/full/289/5/F1153#BIBL ... 14 other HighWire hosted articles, the first 5 are: This article
has been cited by ... [PDF] [Full Text] [Abstract] , April 1, 2009; 24 (4): 1130-1141. ...
Cited by 57 - Related articles - BL Direct - All 6 versions


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