- ►diabetesjournals.org S Srivastava, KV Ramana, R Tammali, SK … - Diabetes, 2006 - Am Diabetes Assoc The objective of this study was to determine whether the polyol pathway enzyme
aldose reductase mediates diabetes abnormalities in vascular smooth muscle cell
(SMC) growth. Aldose reductase inhibitors (tolrestat or sorbinil) or ... Cited by 17 - Related articles - BL Direct - All 7 versions
- ►shouxi.net KV Ramana, A Bhatnagar, S Srivastava, UC … - Journal of Biological Chemistry, 2006 - ASBMB Products of lipid peroxidation such as 4-hydroxy-trans-2-nonenal (HNE) trigger
multiple signaling cascades that variably affect cell growth, differentiation,
and apoptosis. Because glutathiolation is a significant metabolic fate of ... Cited by 37 - Related articles - BL Direct - All 7 versions
- ►shouxi.net KV Ramana, B Friedrich, R Tammali, MB West, … - Diabetes, 2005 - Am Diabetes Assoc Activation of protein kinase C (PKC) has been linked to the development of
secondary diabetes complications. However, the underlying molecular mechanisms
remain unclear. We examined the contribution of aldose reductase, which ... Cited by 47 - Related articles - All 5 versions
KV Ramana, A Bhatnagar, SK Srivastava - FEBS letters, 2004 - Elsevier In this study, we examined the role of aldose reductase (AR) in regulating the
cytotoxic effects of TNF-α on human umbilical vein endothelial cells.
Inhibition of AR by sorbinil or tolrestat prevented TNF-α-induced increase ... Cited by 25 - Related articles - All 5 versions
- ►endojournals.org KV Ramana, R Tammali, A Reddy, A … - Endocrinology, 2007 - Endocrine Soc Diabetes is associated with increased generation of cytokines and tissue
inflammation, but it is unclear how increased cytokine synthesis is causally
related to the development of diabetic complications. Here, we report that ... Cited by 13 - Related articles - BL Direct - All 2 versions
KV Ramana, B Friedrich, S Srivastava, A … - Diabetes, 2004 - Am Diabetes Assoc Activation of the polyol pathway has been linked to the development of secondary
diabetic complications. However, the underlying molecular mechanisms remain
unclear. To probe the contribution of this pathway, we examined whether ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►fasebj.org KV RAMANA, A BHATNAGAR, SK … - The FASEB Journal, 2004 - FASEB Increased expression of adhesion molecules by the activated endothelium is a
critical feature of vascular inflammation associated with several disease states
such as atherosclerosis. However, mechanisms regulating the endothelial ... Cited by 32 - Related articles - BL Direct - All 3 versions
- ►oxfordjournals.org MM Tiwari, KJ Messer, PR Mayeux - Toxicological Sciences, 2006 - Soc Toxicology Since inducible nitric oxide synthase (iNOS) and proximal tubule injury are
known to be critical determinants of lipopolysaccharide (LPS)-induced renal
failure, the role of nitric oxide (NO) in proximal tubule cell apoptosis ... Cited by 3 - Related articles - All 6 versions
- ►endojournals.org SK Srivastava, KV Ramana, A Bhatnagar - Endocrine reviews, 2005 - Endocrine Soc Aldose reductase (AR) is widely expressed aldehyde-metabolizing enzyme. The
reduction of glucose by the AR-catalyzed polyol pathway has been linked to the
development of secondary diabetic complications. Although treatment with AR ... Cited by 97 - Related articles - All 6 versions
B Yang, A Hodgkinson, PJ Oates, BA … - BBA-Molecular Basis of Disease, 2008 - Elsevier The aim of this study was to investigate whether high glucose induces aldose
reductase (AKR1B1) expression through NFκB, which may contribute to the
pathogenesis of diabetic nephropathy. 34 Caucasoid patients with type 1 ... Cited by 5 - Related articles - All 3 versions
