- ►shouxi.net J Buteau, ML Spatz, D Accili - Diabetes, 2006 - Am Diabetes Assoc The glucoincretin hormone glucagon-like peptide-1 (GLP-1) increases pancreatic
β-cell proliferation and survival through sequential activation of the
epidermal growth factor receptor (EGFR), phosphatidylinositol-3 kinase (PI ... Cited by 47 - Related articles - BL Direct - All 4 versions
- ►shouxi.net SC Martinez, C Cras-Méneur, E Bernal- … - Diabetes, 2006 - Am Diabetes Assoc Glucose controls islet β-cell mass and function at least in part through the
phosphatidylinositol 3-kinase (PI3K)/Akt pathway downstream of insulin
signaling. The Foxo proteins, transcription factors known in other tissues ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►nih.gov H Okamoto, D Accili - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Diabetes is associated with defective β cell function and altered β cell mass.
The mechanisms regulating β cell mass and its adaptation to insulin resistance
are unknown. It is unclear whether compensatory β cell hyperplasia is ... Cited by 53 - Related articles - BL Direct - All 12 versions
- ►jbc.org SJ Kim, K Winter, C Nian, M Tsuneoka, Y … - Journal of Biological Chemistry, 2005 - ASBMB The hormone glucose-dependent insulinotropic polypeptide (GIP) potently
stimulates insulin secretion and promotes -cell proliferation and cell survival.
In the present study we identified Forkhead (Foxo1)-mediated suppression of ... Cited by 47 - Related articles - All 5 versions
- ►shouxi.net S Park, X Dong, TL Fisher, S Dunn, AK Omer, … - Journal of Biological Chemistry, 2006 - ASBMB The insulin receptor substrate 2 (Irs2) branch of the insulin/insulin-like
growth factor-signaling cascade prevents diabetes in mice because it promotes β
cell replication, function, and survival, especially during metabolic ... Cited by 65 - Related articles - BL Direct - All 8 versions
- ►jbc.org J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB Diabetes is associated with decreased pancreatic -cell function and mass. It is
unclear whether diabetes treatment should aim at restoring -cell
performance/mass or at inducing " -cell rest" to prevent further ... Cited by 20 - Related articles - All 6 versions
- ►sciencesignaling.org GG Holz, OG Chepurny - Science's STKE, 2005 - stke.sciencemag.org Glucagon-like peptide-1-(7-36)-amide (GLP-1), a hormone secreted by endocrine L
cells of the intestinal tract, has unique insulinotropic and growth
factor–like signal transduction properties that indicate its usefulness ... Cited by 17 - Related articles - All 24 versions
- ►endocrinology-journals.org MJ Kim, JH Kang, YG Park, GR Ryu, SH Ko, … - Journal of Endocrinology, 2006 - Soc Endocrinology Glucagon-like peptide-1 (GLP-1) and its analog exendin-4 (EX) have been
considered as a growth factor implicated in pancreatic islet mass increase and
ß-cell proliferation. This study aimed to investigate the effect of EX on ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►nih.gov T Kitamura, J Nakae, Y Kitamura, Y Kido, WH … - Journal of Clinical Investigation, 2002 - Am Soc Clin Investig Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of
insulin-producing β cells. The mechanisms governing replication of terminally
differentiated β cells and neogenesis from progenitor cells are unclear. ... Cited by 211 - Related articles - BL Direct - All 11 versions
- ►diabetesjournals.org J Buteau, S Foisy, E Joly, M Prentki - Diabetes, 2003 - Am Diabetes Assoc We previously provided evidence that glucagon-like peptide 1 (GLP-1) induces
pancreatic ß-cell growth nonadditively with glucose in a phosphatidylinositol
(PI) 3-kinase- and protein kinase C -dependent manner. However, the exact ... Cited by 146 - Related articles - BL Direct - All 5 versions
