- ►diabetesjournals.org K Imoto, D Kukidome, T Nishikawa, T Matsuhisa, K … - Diabetes, 2006 - Am Diabetes Assoc Tumor necrosis factor (TNF)-α inhibits insulin action; however, the precise mechanisms are
unknown. It was reported that TNF-α could increase mitochondrial reactive oxygen species
(ROS) production, and apoptosis signal–regulating kinase 1 (ASK1) was reported to be ... Cited by 36 - Related articles - BL Direct - All 5 versions
T Nishikawa, D Kukidome, K Sonoda, K Fujisawa, T … - Diabetes Research and …, 2007 - Elsevier Tumor necrosis factor-alpha (TNF-α) inhibits insulin action, in part, by activating c-jun NH 2 -terminal
kinases (JNK). However, the precise mechanisms by which TNF-α activates JNK are
unknown. Recently, we confirmed that hyperglycemia increased mitochondrial reactive ... Cited by 9 - Related articles - All 9 versions
T Nishikawa, E Araki - Antioxidants & Redox Signaling, 2007 - liebertonline.com T HE MITOCHONDRION is believed to be an organelle derived from a genetic component(s)
of microorganisms, and thus its replication, transcription, and translation system has been developed
on its own basis, although several nuclear genome–encoded proteins are also essential ... Cited by 51 - Related articles - BL Direct - All 4 versions
T Takamura, H Misu, T Yamashita, S … - Current Pharmaceutical …, 2008 - ingentaconnect.com Abstract: Type 2 diabetes is a multifactorial disease that is caused by the disruption of inter-organ
networks. These dis- ruptions lead to absolute and/or relative deficiencies in the actions of insulin
due to either a genetic disposition or envi- ronmental factors. Specifically, the liver plays a ... Cited by 2 - Related articles - All 3 versions
A Bloch-Damti, R Potashnik, P Gual, Y Le Marchand- … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Induction of stress kinases leading to serine hyperphosphorylation
of IRS1 may link oxidative stress to insulin resistance. The aim of this study was to investigate
the roles of the phosphorylated serine residues Ser307 and Ser632, two sites implicated ... Cited by 23 - Related articles - BL Direct - All 4 versions
JR Hwang, C Zhang, C Patterson - Cell Stress & Chaperones, 2005 - pubmedcentral.nih.gov Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein kinase kinase kinase
(MAPKKK) that is regulated under conditions of cellular stress. ASK1 phosphorylates c-Jun
N-terminal kinase (JNK) and elicits an apoptotic response. ASK1 activity is regulated at ... Cited by 23 - Related articles - All 10 versions
P Gual, T Gremeaux, T Gonzalez, YL Marchand-Brustel … - Diabetologia, 2003 - Springer Aim/hypothesis. Insulin-induced IRS-1 serine phos- phorylation could be physiologically important
to reg- ulate insulin action. In a hyperinsulinaemic state such as obesity or Type 2 diabetes, this
phosphorylation could be modified and exacerbate insulin resistance. We aimed at ... Cited by 70 - Related articles - BL Direct - All 4 versions
A Rudich, H Kanety, N Bashan - Trends in Endocrinology & Metabolism, 2007 - Elsevier Obesity has been proposed to inflict a variety of stresses on adipose tissue, including
inflammatory, metabolic, oxidative and endoplasmic reticulum stress. Through the activation
of 'stress-sensing pathways', metabolic and endocrine alterations are produced, which ... Cited by 6 - Related articles - All 4 versions
CJ Carlson, CM Rondinone - Metabolism, 2005 - Elsevier Inhibition of p38, a member of the mitogen-activated protein kinase family, has been shown to
prevent the loss of GLUT4 protein expression in insulin-resistant adipocytes without improving
insulin receptor substrate 1 (IRS-1) protein levels and presumably insulin signaling. Thus, ... Cited by 8 - Related articles - All 6 versions
EH Goldman, L Chen, H Fu - Journal of Biological Chemistry, 2004 - ASBMB Oxidative stress has been indicated in a variety of pathological processes such as
atherosclerosis, diabetes, and neurodegenerative diseases. Understanding how intracellular
signaling pathways respond to oxidative insults such as hydrogen peroxide (H 2 O 2 ) ... Cited by 77 - Related articles - BL Direct - All 6 versions
