MC García, I Wernstedt, A Berndtsson, M Enge, M Bell, … - Diabetes, 2006 - Am Diabetes Assoc Interleukin-1 (IL-1) is a major mediator of inflammation that exerts its biological activities through
the IL-1 type I receptor (IL-1RI). The body weights of IL-1RI −/− mice of both sexes started to deviate
from those of wild-type mice at 5–6 months of age and were 20% higher at 9 months of ... Cited by 37 - Related articles - BL Direct - All 7 versions
D Chida, T Osaka, O Hashimoto, Y Iwakura - Diabetes, 2006 - Am Diabetes Assoc Proinflammatory cytokines including interleukin (IL)-1 and IL-6 exert pleiotropic effects on the
neuro-immuno-endocrine system. Previously, we showed that IL-1 receptor antagonist–deficient
(IL-1Ra −/− ) mice show a lean phenotype due to an abnormal lipid metabolism. On the ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►endojournals.org L Strandberg, M Lorentzon, A Hellqvist, S … - Journal of Clinical …, 2006 - Endocrine Soc Context: There is growing evidence for interactions between the regulation of body fat and the
immune system. Studies of knockout mice indicate that IL-1 has an antiobesity effect. ...
Objective: The objective of the study was to investigate our hypothesis that common ... Cited by 12 - Related articles - BL Direct - All 9 versions
- ►rupress.org T Matsuki, R Horai, K Sudo, Y Iwakura - Journal of Experimental …, 2003 - jem.rupress.org IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role
of this cytokine under physiological conditions is not known completely. In this paper, we analyzed
the role of IL-1 in maintaining body weight because IL-1 receptor antagonist–deficient (IL- ... Cited by 81 - Related articles - BL Direct - All 6 versions
E Somm, E Henrichot, A Pernin, CE Juge-Aubry, P … - Diabetes, 2005 - Am Diabetes Assoc Interleukin (IL)-1 is a regulator of inflammation but is also implicated in the control of energy
homeostasis. Because the soluble IL-1 receptor antagonist (IL-1Ra) is markedly increased in
the serum of obese patients and is overexpressed in white adipose tissue in obesity, we ... Cited by 30 - Related articles - BL Direct - All 5 versions
- ►pnas.org EP Zorrilla, M Sanchez-Alavez, S … - Proceedings of the …, 2007 - National Acad Sciences Circulating levels of the cytokine interleukin 18 (IL-18) are elevated in obesity. Here, we show
that administration of IL-18 suppresses appetite, feed efficiency, and weight regain in food-deprived
male and female C57BL/6J mice. Intraperitoneal vs. intracerebroventricular routes of ... Cited by 17 - Related articles - BL Direct - All 8 versions
- ►nih.gov JA Reed, DJ Clegg, KB Smith, EG Tolod- … - Journal of Clinical …, 2005 - Am Soc Clin Investig Many proinflammatory cytokines, such as leptin, play key roles in dynamic regulation of energy
expenditure and food intake. The present work tested a role for the proinflammatory cytokine
GM-CSF. Central but not peripheral administration of GM-CSF to adult rats significantly ... Cited by 17 - Related articles - BL Direct - All 10 versions
CE Juge-Aubry, E Somm, V Giusti, A Pernin, R … - Diabetes, 2003 - Am Diabetes Assoc The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein
intervening in the counterregulation of inflammatory processes. We previously showed that this
cytokine antagonist is upregulated in the serum of obese patients, correlating with BMI ... Cited by 95 - Related articles - BL Direct - All 4 versions
MG Netea, LAB Joosten, E Lewis, DR Jensen, PJ … - Nature - 140.116.93.232 Here we report the presence of hyperphagia, obesity and insulin resistance in knockout mice
deficient in IL-18 or IL-18 receptor, and in mice transgenic for expression of IL-18 binding
protein. Obesity of Il18Ā/Ā mice resulted from accumulation of fat tissue based on ... Cited by 61 - Related articles - View as HTML - BL Direct - All 14 versions
L Strandberg, D Mellström, Ö Ljunggren, E Grundberg, … - Obesity, 2008 - nature.com There is growing evidence that immune functions are linked to the regulation of body fat. Our
studies of knockout mice indicate that both endogenous interleukin (IL)-6 and IL-1 can suppress
mature-onset obesity. We now investigated whether four common polymorphisms of the ... Cited by 6 - Related articles - All 2 versions
