A Riboulet-Chavey, A Pierron, I Durand, J Murdaca, J … - Diabetes, 2006 - Am Diabetes Assoc Nonenzymatic glycation is increased in diabetes and leads to elevated levels of advanced glycation
end products (AGEs), which link hyperglycemia to the induction of insulin resistance. In hyperglycemic
conditions, intracellularly formed α-ketoaldehydes, such as methylglyoxal, are an ... Cited by 26 - Related articles - BL Direct - All 5 versions
- ►fasebj.org X Jia, DJH Olson, ARS Ross, L Wu - The FASEB Journal, 2006 - FASEB Elevated methylglyoxal (MG) levels have been reported in insulin-resistance syndrome. The
present study investigated whether MG, a highly reactive metabolite of glucose, induced structural
and functional changes of insulin. Incubation of human insulin with MG in vitro yielded ... Cited by 23 - Related articles - BL Direct - All 5 versions
- ►fasebj.org AV Cantero, M Portero-Otin, V Ayala, N Auge, M … - The FASEB Journal, 2007 - FASEB Purpose: Low molecular weight carbonyl compounds, such as the -ketoaldehydes methylglyoxal
(MGO) and glyoxal (GO), are formed under hyperglycemic conditions and behave as advanced
glycation end product (AGE) precursors. They form adducts on proteins, thereby inducing ... Cited by 15 - Related articles - BL Direct - All 3 versions
T Chang, R Wang, L Wu - Free Radical Biology and Medicine, 2005 - Elsevier Methylglyoxal (MG) is a metabolite of glucose. Our previous study demonstrated an elevated
MG level with an increased oxidative stress in vascular smooth muscle cells (VSMCs) from spontaneously
hypertensive rats. Whether MG causes the generation of nitric oxide (NO) and superoxide ... Cited by 44 - Related articles - All 4 versions
J Du, J Zeng, X Ou, X Ren, S Cai - … Journal of Biochemistry and Cell Biology, 2006 - Elsevier Abnormal accumulation of methylglyoxal, a physiological glucose metabolite, is considered a
potential link between hyperglycemia and diabetes complications. Evidence has shown that
methylglyoxal modifies cellular proteins by glycation and oxidation, resulting in ... Cited by 9 - Related articles - All 3 versions
PJ Thornalley - Drug metabolism and drug interactions, 2008 - pubmedcentral.nih.gov Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal – physiological
substrates of glyoxalase 1 - is potentially damaging to the proteome, genome and lipidome. Glyoxalase
1 suppresses glycation by these α-oxoaldehyde metabolites and thereby represents part ... Cited by 11 - Related articles - BL Direct - All 5 versions
WH Chan, HJ Wu, NH Shiao - Journal of cellular biochemistry, 2007 - interscience.wiley.com Methylglyoxal (MG) is a reactive dicarbonyl compound endogenously produced mainly from
glycolytic intermediates. MG is cytotoxic through induction of cell death, and elevated MG levels
in diabetes patients are believed to contribute to diabetic complications. In this report, we ... Cited by 14 - Related articles - BL Direct - All 4 versions
M Fukunaga, S Miyata, S Higo, Y Hamada … - ANNALS-NEW …, 2005 - interscience.wiley.com Abstract: Although recent studies have suggested the potential involvement of apoptotic cell
death in the development of diabetic neuropathy, the precise mechanism remains to be
elucidated. On the other hand, it is known that the formation of methylglyoxal (MG), a ... Cited by 18 - Related articles - BL Direct - All 5 versions
S Di Loreto, V Zimmitti, P Sebastiani, C Cervelli, S … - International Journal of …, 2008 - Elsevier The hippocampus is known to play a crucial role in learning and memory. Recent data from literature
show that cognitive problems, common to aged or diabetic patients, may be related to accumulation
of toxic α-oxoaldehydes such as methylglyoxal. Thus, it is possible that methylglyoxal ... Cited by 8 - Related articles - All 3 versions
MP Kalapos - Chemico-Biological Interactions, 2008 - Elsevier Methylglyoxal is an α-oxoaldehyde inevitably produced from triose-phosphate intermediates
of phosphorylating glycolysis, and also from amino acids and acetone. Recently, the attention
has been focused on the involvement of free radicals in methylglyoxal toxicity. In this ... Cited by 9 - Related articles - All 2 versions
