- ►diabetesjournals.org M López, CJ Lelliott, S Tovar, W Kimber, R Gallego, S … - Diabetes, 2006 - Am Diabetes Assoc Fatty acid metabolism in the hypothalamus has recently been shown to regulate feeding. The selective
estrogen receptor modulator tamoxifen (TMX) exerts a potent anorectic effect. Here, we show that the
anorectic effect of TMX is ... Cited by 38 - Related articles - BL Direct - All 8 versions
- ►cell.com M López, R Lage, AK Saha, D Pérez-Tilve, MJ Vázquez … - Cell metabolism, 2008 - Elsevier Current evidence suggests that hypothalamic fatty acid metabolism may play a role in regulating food
intake; however, confirmation that it is a physiologically relevant regulatory system of feeding is
still incomplete. Here, we use ... Cited by 30 - Related articles - All 8 versions
- ►simplifica.net [PDF] M López, S Tovar, MJ Vázquez, LM … - Proceedings of the …, 2007 - Cambridge Univ Press More than 70 years ago the glucostatic, lipostatic and aminostatic hypotheses proposed that the
central nervous system sensed circulating levels of different metabolites, changing feeding
behaviour in response to the levels ... Cited by 19 - Related articles - BL Direct - All 10 versions
M López, CJ Lelliott, A Vidal-Puig - Bioessays, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets. In
this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the ... Cited by 13 - Related articles - BL Direct - All 3 versions
MJ Wolfgang, T Kurama, Y Dai, A Suwa, M Asaumi, S … - 2006 - National Acad Sciences Fatty acid synthesis in the central nervous system is implicated in the control of food intake and
energy expenditure. An intermediate in this pathway, malonyl-CoA, mediates these effects.
Malonyl-CoA is an established ... Cited by 45 - Related articles - BL Direct - All 10 versions
SH Cha, JT Rodgers, P Puigserver, S … - Proceedings of the …, 2006 - National Acad Sciences Previous investigations show that intracerebroventricular administration of a potent inhibitor of
fatty acid synthase, C75, increases the level of its substrate, malonyl-CoA, in the hypothalamus.
The “malonyl-CoA signal” is ... Cited by 27 - Related articles - BL Direct - All 13 versions
- ►pnas.org Z Hu, SH Cha, S Chohnan, MD … - Proceedings of the …, 2003 - National Acad Sciences Previous studies showed that ip administration of C75, a potent inhibitor of fatty acid synthase
(FAS), blocked fasting-induced up-regulation of orexigenic neuropeptides and down-regulation of
anorexigenic neuropeptides in the ... Cited by 102 - Related articles - BL Direct - All 10 versions
Z Hu, Y Dai, M Prentki, S Chohnan, MD Lane - Journal of Biological Chemistry, 2005 - ASBMB The cellular level of malonyl-CoA, an intermediate in fatty acid biosynthesis, depends on its rate
of synthesis catalyzed by acetyl-CoA carboxylase relative to its rate of utilization and degradation
catalyzed by fatty acid synthase ... Cited by 50 - Related articles - BL Direct - All 6 versions
- ►physiology.org EK Kim, I Miller, LE Landree, FF Borisy- … - American Journal of …, 2002 - Am Physiological Soc We previously demonstrated that C75, a specific and potent inhibitor of fatty acid synthase (FAS),
reduced food intake and decreased body weight in mice. In the present study, we determined that
these effects were not due to ... Cited by 75 - Related articles - BL Direct - All 4 versions
