- ►diabetesjournals.org T Rydgren, D Bengtsson, S Sandler - Diabetes, 2006 - Am Diabetes Assoc Cytokines, particularly interleukin (IL)-1β, have been postulated to cause β-cell destruction in
type 1 diabetes. We tested the efficacy of an IL-1 cytokine trap in counteraction of suppressive
and toxic effects after exposure of rat pancreatic islets in vitro to IL-1β. The IL-1 cytokine ... Cited by 8 - Related articles - BL Direct - All 5 versions
M Pedulla, R d'Aquino, V Desiderio, F de … - Journal of cellular …, 2007 - interscience.wiley.com Pancreatic islets are commonly isolated for research and transplantation without taking into consideration
that they undergo mechanical or chemical stress during this process. In order to counteract both
types of injuries, the compound AEOL10150, a novel MnSOD mimic, was added during ... Cited by 4 - Related articles - BL Direct - All 4 versions
MS Hanson, A Steffen, JS Danobeitia, B Ludwig … - Cell …, 2008 - ingentaconnect.com The objective of this study was to develop a multiparametric flow cytometry assay to simultaneously
quantify isolated pancreatic islet cell viability, apoptosis, and glucose-induced metabolic
flux. INS-1 and rat islet β-cells were stained with fluorescent probes for cell viability ... Cited by 3 - Related articles
C Botsios, P Sfriso, A Furlan, P Ostuni, M Biscaro, U … - Reumatismo - ncbi.nlm.nih.gov OBJECTIVE: We evaluated both the efficacy and safety of anakinra in daily routine rheumatoid
arthritis clinical practice. METHODS: We studied 60 cases, including patients with previous
anti-TNFalpha exposure, treated with anakinra (100 mg/daily sc) in combination with ... Cited by 4 - Related articles - BL Direct
A Schwarznau, MS Hanson, JM Sperger, BR … - Journal of cellular …, 2009 - ncbi.nlm.nih.gov Pro-inflammatory cytokines (PIC) impair islet viability and function by activating inflammatory
pathways that induce both necrosis and apoptosis. The aim of this study was to utilize an in vitro
rat islet model to evaluate the efficacy of a clinically approved IL-1 receptor antagonist ( ... Related articles
A Schwarznau, MS Hanson, JM Sperger, BR Schram, … - interscience.wiley.com Pro-inflammatory cytokines (PIC) impair islet viability and function by activating inflammatory
pathways that induce both necrosis and apoptosis. The aim of this study was to utilize an in vitro
rat islet model to evaluate the efficacy of a clinically approved IL-1 receptor antagonist ( ... Related articles
- ►nih.gov [PDF] N Welsh, K Bendtzen, M Welsh - Journal of Clinical Investigation, 1995 - pubmedcentral.nih.gov A hybrid gene consisting of the insulin gene enhancer/pro- moter region, the signal
sequence, the insulin B- and C- chains, and the human interleukin-1 receptor antagonist
(IL-ira) gene was constructed. This hybrid gene was transfected together with the ... Cited by 8 - Related articles - BL Direct - All 7 versions
- ►pnas.org S Roy, JR Sharom, C Houde, TP Loisel, … - Proceedings of the …, 2008 - National Acad Sciences Caspase-12 is a dominant-negative regulator of caspase-1 (IL-1β-converting enzyme) and an
attenuator of cytokine responsiveness to septic infections. This molecular role for caspase-12
appears to be akin to the role of cFLIP in regulating caspase-8 in the extrinsic cell death ... Cited by 8 - Related articles - BL Direct - All 7 versions
