- ►diabetesjournals.org EP Kwan, L Xie, L Sheu, CJ Nolan, M Prentki, … - Diabetes, 2006 - Am Diabetes Assoc Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic
vesicle priming. We recently showed that Munc13-1 is expressed in rodent and
human islet β-cells and that its levels are reduced in islets of type 2 ... Cited by 21 - Related articles - All 5 versions
- ►cell.com L Kang, Z He, P Xu, J Fan, A Betz, N Brose, T … - Cell Metabolism, 2006 - Elsevier Munc13-1 is a presynaptic protein that is essential for synaptic vesicle
priming. Deletion of Munc13-1/unc13 causes total arrest of synaptic transmission
due to a complete loss of fusion-competent synaptic vesicles. The ... Cited by 23 - Related articles - All 13 versions
EP Kwan, HY Gaisano - Diabetes Obes Metab, 2007 - interscience.wiley.com Exocytosis of insulin vesicles in the pancreatic β-cell involves a sequence of
regulated events, whose normal function and efficient adaptation to increased
demand are essential for the maintenance of glucose homeostasis. These ... Cited by 4 - Related articles - All 2 versions
- ►jbc.org L Sheu, EA Pasyk, J Ji, X Huang, X Gao, F … - Journal of Biological Chemistry, 2003 - ASBMB The slower kinetics of insulin release from pancreatic islet beta cells, as
compared with other regulated secretory processes such as chromaffin granule
secretion, can in part be explained by the small number of the insulin ... Cited by 51 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org W Zhang, L Lilja, SA Mandic, J Gromada, K … - Diabetes, 2006 - Am Diabetes Assoc Tomosyn, a syntaxin-binding protein, is capable of dissociating mammalian
homolog of the Caenorhabditis elegans unc-18 gene from syntaxin and is involved
in the regulation of exocytosis. We have investigated the expression, ... Cited by 15 - Related articles - BL Direct - All 5 versions
DR Stevens, ZX Wu, U Matti, HJ Junge, C … - Current Biology, 2005 - Elsevier Most nerve cells communicate with each other through synaptic transmission at
chemical synapses. The regulated exocytosis of neurotransmitters, hormones, and
peptides occurs at specialized membrane areas through Ca 2+ -triggered ... Cited by 36 - Related articles - All 15 versions
- ►shouxi.net EP Kwan, L Xie, L Sheu, T Ohtsuka, HY … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are
rescued by Epac2 and PKA, we used patch-clamp capacitance measurements, showing
that 1) cAMP restored the reduced readily releasable pool (RRP) and ... Cited by 16 - Related articles - BL Direct - All 4 versions
JM Madison, S Nurrish, JM Kaplan - Current Biology, 2005 - Elsevier Neurotransmitter secretion at synapses is controlled by several
processes—morphological docking of vesicles at release sites, priming of
docked vesicles to make them fusion competent, and calcium-dependent fusion ... Cited by 35 - Related articles - All 9 versions
- ►shouxi.net YS Andrews-Zwilling, H Kawabe, K Reim, F … - Journal of Biological Chemistry, 2006 - ASBMB Transmitter release at synapses between nerve cells is spatially restricted to
active zones, where synaptic vesicle docking, priming, and Ca 2+ -dependent
fusion take place in a temporally highly coordinated manner. Munc13s are ... Cited by 18 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in
hormone-sensitive lipase-null mice (HSL −/− ), both in vivo and in vitro.
The focus of the current study was to gain further insight into the ... Cited by 34 - Related articles - BL Direct - All 6 versions
