LH Clerk, MA Vincent, LA Jahn, Z Liu, JR Lindner, EJ … - Diabetes, 2006 - Am Diabetes Assoc We have previously shown that skeletal muscle capillaries are rapidly recruited by physiological
doses of insulin in both humans and animals. This facilitates glucose and insulin delivery to
muscle, thus augmenting glucose uptake. In obese rats, both insulin-mediated ... Cited by 56 - Related articles - BL Direct - All 5 versions
MA Vincent, LH Clerk, JR Lindner, AL Klibanov, MG … - Diabetes, 2004 - Am Diabetes Assoc Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow and
to recruit muscle capillaries (by relaxing resistance and terminal arterioles, respectively). ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►physiology.org MA Vincent, LH Clerk, JR Lindner, WJ … - American Journal of …, 2006 - Am Physiological Soc Intense exercise and insulin each increases total limb blood flow and recruits muscle
capillaries, presumably to facilitate nutrient exchange. Whether mixed meals or light exercise
likewise recruits capillaries is unknown. We fed 18 (9 M, 9 F) healthy volunteers a ... Cited by 30 - Related articles - BL Direct - All 2 versions
- ►diabetesjournals.org M Coggins, J Lindner, S Rattigan, L Jahn, E Fasy, S … - Diabetes, 2001 - Am Diabetes Assoc Despite intensive study, the relation between insulin's action on blood flow and glucose metabolism
remains unclear. Insulin-induced changes in microvascular perfusion, independent from effects
on total blood flow, could be an important variable contributing to insulin's metabolic ... Cited by 97 - Related articles - BL Direct - All 5 versions
L Zhang, MA Vincent, SM Richards, LH Clerk, S … - Diabetes, 2004 - Am Diabetes Assoc We have reported that insulin exerts two vascular actions in muscle; it both increases blood flow
and recruits capillaries. In parallel hyperinsulinemic-euglycemic clamp studies, we compared
the insulin dose response of muscle microvascular recruitment and femoral blood flow as ... Cited by 57 - Related articles - BL Direct - All 5 versions
- ►physiology.org MA Vincent, EJ Barrett, JR Lindner, MG … - American Journal of …, 2003 - Am Physiological Soc We examined the effects of inhibiting nitric oxide synthase with N -nitro-L-arginine-methyl ester
(L-NAME) on total hindlimb blood flow, muscle microvascular recruitment, and hindlimb glucose
uptake during euglycemic hyperinsulinemia in vivo in the rat. We used two independent ... Cited by 89 - Related articles - BL Direct - All 3 versions
MG Wallis, CM Wheatley, S Rattigan, EJ Barrett, ADH … - Diabetes, 2002 - Am Diabetes Assoc Insulin-mediated hemodynamic effects in muscle were assessed in relation to insulin resistance
in obese and lean Zucker rats. Whole-body glucose infusion rate (GIR), femoral blood flow
(FBF), hindleg glucose extraction (HGE), hindleg glucose uptake (HGU), 2-deoxyglucose ( ... Cited by 59 - Related articles - BL Direct - All 4 versions
LH Clerk, S Rattigan, MG Clark - Diabetes, 2002 - Am Diabetes Assoc Infusion of triglycerides and heparin causes insulin resistance in muscle. Because the vascular
actions of insulin, particularly capillary recruitment, may contribute to the increase in glucose
uptake by skeletal muscle, we investigated the effects of Intralipid/heparin infusion on the ... Cited by 76 - Related articles - BL Direct - All 5 versions
- ►endojournals.org S Gudbjornsdottir, M Sjostrand, L Strindberg, P … - Journal of Clinical …, 2005 - Endocrine Soc Capillary recruitment in muscles, induced by insulin, has been proposed to be impaired in
insulin-resistant states. To elucidate the mechanisms regulating capillary transport of insulin
and glucose in type 2 diabetes, we directly calculated the permeability-surface area ... Cited by 22 - Related articles - All 5 versions
LH Clerk, MA Vincent, JR Lindner, MG Clark, … - Diabetes/Metabolism … - interscience.wiley.com Whether a discrete vascular action of insulin in skeletal muscle integrally participates in
insulin-mediated glucose disposal has been extensively examined but remains a contentious
issue. Here, we review some of the data both supporting and questioning the role of ... Cited by 33 - Related articles - BL Direct - All 4 versions
