SC Martinez, C Cras-Méneur, E Bernal-Mizrachi, MA … - Diabetes, 2006 - Am Diabetes Assoc Glucose controls islet β-cell mass and function at least in part through the phosphatidylinositol
3-kinase (PI3K)/Akt pathway downstream of insulin signaling. The Foxo proteins, transcription
factors known in other tissues to be negatively regulated by Akt activation, affect ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►nih.gov H Okamoto, D Accili - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Diabetes is associated with defective β cell function and altered β cell mass. The mechanisms
regulating β cell mass and its adaptation to insulin resistance are unknown. It is unclear whether
compensatory β cell hyperplasia is achieved via proliferation of existing β cells or ... Cited by 54 - Related articles - BL Direct - All 12 versions
J Buteau, ML Spatz, D Accili - Diabetes, 2006 - Am Diabetes Assoc The glucoincretin hormone glucagon-like peptide-1 (GLP-1) increases pancreatic β-cell proliferation
and survival through sequential activation of the epidermal growth factor receptor (EGFR),
phosphatidylinositol-3 kinase (PI 3-kinase), and Akt. We investigated the role of ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►jbc.org J Buteau, A Shlien, S Foisy, D Accili - Journal of Biological Chemistry, 2007 - ASBMB Diabetes is associated with decreased pancreatic -cell function and mass. It is unclear whether
diabetes treatment should aim at restoring -cell performance/mass or at inducing " -cell rest"
to prevent further deterioration. The transcription factor Foxo1 protects -cells against ... Cited by 20 - Related articles - All 6 versions
- ►jbc.org D Kawamori, H Kaneto, Y Nakatani, T Matsuoka, M … - Journal of Biological …, 2006 - ASBMB It has been shown that oxidative stress and activation of the c-Jun N-terminal kinase (JNK) pathway
induce the nucleocytoplasmic translocation of the pancreatic transcription factor PDX-1, which
leads to pancreatic -cell dysfunction. In this study, we have shown that the forkhead ... Cited by 43 - Related articles - BL Direct - All 8 versions
M Ohsugi, C Cras-Meneur, Y Zhou, E Bernal- … - Journal of Biological …, 2005 - ASBMB Running Title: Multiple roles of insulin signaling in islet cells ... Reduced Expression of the Insulin
Receptor in Mouse Insulinoma (MIN6) Cells Reveals Multiple Roles of Insulin Signaling in Gene
Expression, Proliferation, Insulin Content and Secretion. ... Mitsuru Ohsugi, Corentin ... Cited by 39 - Related articles - All 5 versions
- ►cell.com YI Kitamura, T Kitamura, JP Kruse, JC Raum, R Stein, … - Cell metabolism, 2005 - Elsevier Diabetes causes pancreatic β cell failure through hyperglycemia-induced oxidative stress, or
“glucose toxicity.” We show that the forkhead protein FoxO1 protects β cells against oxidative
stress by forming a complex with the promyelocytic leukemia protein Pml and the NAD- ... Cited by 105 - Related articles - All 14 versions
- ►physiology.org S Srinivasan, E Bernal-Mizrachi, M Ohsugi … - American Journal of …, 2002 - Am Physiological Soc The concentration of glucose in plasma is an important determinant of pancreatic -cell mass,
whereas the relative contributions of hypertrophy, proliferation, and cell survival to this process
are unclear. Glucose results in depolarization and subsequent calcium influx into islet ... Cited by 62 - Related articles - BL Direct - All 5 versions
T Kitamura, KY Ido - Endocrine journal, 2007 - ncbi.nlm.nih.gov Forkhead transcription factors of the FoxO family have important roles in cellular
proliferation, apoptosis, differentiation and stress resistance. FoxO proteins also play important
roles in metabolism of complex organisms. FoxO1 regulates glucose and lipid ... Cited by 12 - Related articles - BL Direct
SC Martinez, K Tanabe, C Cras-Méneur, NA Abumrad, … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Increasing fatty acid concentrations (100–400 μmol/l palmitate or oleate) led to early
Jun NH 2 -terminal kinase (JNK) activation that preceded induction of ER stress markers and
apoptosis. Foxo1 activity was increased with fatty acid administration and by ... Cited by 15 - Related articles - BL Direct - All 4 versions
