- ►diabetesjournals.org F Lalloyer, B Vandewalle, F Percevault, G Torpier, J … - Diabetes, 2006 - Am Diabetes Assoc Peroxisome proliferator–activated receptor (PPAR) α is a transcription factor controlling lipid
and glucose homeostasis. PPARα-deficient (−/−) mice are protected from high-fat diet–induced
insulin resistance. However, the impact of PPARα in the pathophysiological setting of ... Cited by 35 - Related articles - BL Direct - All 6 versions
J Kerr-Conte, M Oosterveer, R Paumelle, JC Fruchart, F … - DIABETES, 2006 - Am Diabetes Assoc Page 1. Original Article Peroxisome Proliferator–Activated Receptor Improves Pancreatic
Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets Fanny
Lalloyer, 1,2,3 Brigitte Vandewalle, 4 Frédéric Percevault, 1,2,3 Gérard Torpier, 1,2,3 ... Related articles
- ►endocrinology-journals.org [PDF] MJ Holness, ND Smith, GK Greenwood, MC … - Journal of …, 2003 - Soc Endocrinology Abnormal depletion or accumulation of islet lipid may be important for the development of pancreatic
cell failure. Long-term lipid sensing by cells may be co-ordinated via peroxisome
proliferator-activated receptors (PPARs). We investigated whether PPAR activation in vivo ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►endojournals.org K Ravnskjaer, M Boergesen, B Rubi, JK Larsen, T … - Endocrinology, 2005 - Endocrine Soc Fatty acids (FAs) are known to be important regulators of insulin secretion from pancreatic
ß-cells. FA-coenzyme A esters have been shown to directly stimulate the secretion process, whereas
long-term exposure of ß-cells to FAs compromises glucose-stimulated insulin secretion ( ... Cited by 45 - Related articles - BL Direct - All 2 versions
L Andrulionytė, O Laukkanen, JL Chiasson, M … - Journal of Molecular …, 2006 - Springer Page 1. J Mol Med (2006) 84: 701–708 DOI 10.1007/s00109-006-0063-3 ORIGINAL ARTICLE
Laura Andrulionytė . Olli Laukkanen . Jean-Louis Chiasson . Markku Laakso . STOP-NIDDM
Study Group Single nucleotide polymorphisms of the HNF4α gene are ... Cited by 9 - Related articles - All 4 versions
- ►jlr.org K Tordjman, KN Standley, C Bernal-Mizrachi, TC … - The Journal of Lipid …, 2002 - ASBMB Fatty acids may promote type 2 diabetes by altering insulin secretion from pancreatic ß cells,
a process known as lipotoxicity. The underlying mechanisms are poorly understood. To test the
hypothesis that peroxisome proliferator-activated receptor (PPAR ) has a direct effect on ... Cited by 68 - Related articles - BL Direct - All 5 versions
H Yoshikawa, Y Tajiri, Y Sako, T Hashimoto, F … - European journal of …, 2001 - Elsevier Bezafibrate is an activator of peroxisome proliferator-activated receptors (PPAR) α. The present
study was performed to investigate the effects of bezafibrate and the PPAR α activator,
4-Cholro-6-(2.3-xylidino)-2-pyrimidin-ylthio acetic acid (WY14643), on the β-cell function ... Cited by 13 - Related articles - All 5 versions
EH Koh, MS Kim, JY Park, HS Kim, JY Youn, HS Park, … - Diabetes, 2003 - Am Diabetes Assoc Lipid accumulation in nonadipose tissues is closely related to the development of type 2 diabetes
in obese subjects. We examined the potential preventive effect of peroxisome proliferator-activated
receptor (PPAR)-α and PPAR-γ stimulation on the development of diabetes in obese ... Cited by 104 - Related articles - BL Direct - All 6 versions
DM Flavell, H Ireland, JW Stephens, E Hawe, J … - Diabetes, 2005 - Am Diabetes Assoc Dysregulation of fatty acid metabolism is important in the pathogenesis of type 2 diabetes. Peroxisome
proliferator-activated receptor (PPAR)α is a master regulator of fatty acid catabolism, and PPARα
activators delay the onset of type 2 diabetes. We examined association between three ... Cited by 41 - Related articles - All 7 versions
JR Gavin… - The American journal of cardiology, 2001 - Elsevier The role of postprandial hyperglycemia in the etiology of diabetes-related complications and
outcomes, although still being elucidated, is greater than previously thought. Acute glucose elevations
after meal ingestion are associated with a variety of glucose-mediated tissue defects— ... Cited by 25 - Related articles - BL Direct - All 11 versions
