T Yokoi, K Fukuo, O Yasuda, M Hotta, J Miyazaki, Y … - Diabetes, 2006 - Am Diabetes Assoc Vascular ageing is accelerated in patients with diabetes. However, the underlying mechanism
remains unclear. Here, we show that high glucose induces activation of apoptosis signal-regulating
kinase 1 (ASK1), an apoptosis-inducing signal that mediates endothelial cell senescence ... Cited by 16 - Related articles - BL Direct - All 6 versions
H TAKASE, A HASHIMOTO, R OKUTSU, Y HIROSE, … - Arzneimittel-Forschung, 2007 - cat.inist.fr To investigate whether cilostazol(CAS 73963-72-1), a selective phosphodiesterase 3
inhibitor, reduces the progression of atherogenic diet-induced atherosclerosis, cilostazol was
orally administered twice a day for 4 weeks to male apolipoprotein-E knockout(ApoE KO) ... Cited by 2 - Related articles - BL Direct - All 3 versions
- ►ahajournals.org H Ota, M Eto, MR Kano, S Ogawa, K Iijima, M … - … , and vascular biology, 2008 - Am Heart Assoc Methods and Results— Prematurely senescent human umbilical vein endothelial cells
(HUVECs) were induced by treatment with hydrogen peroxide (H 2 O 2 ) as judged by
senescence-associated β-galactosidase assay (SA-βgal), cell morphological ... Cited by 16 - Related articles - All 5 versions
- ►boar.or.kr [PDF] H Ota, M Akishita, M Eto, K Iijima, M Kaneki, Y … - Journal of molecular and …, 2007 - Elsevier Yeast Sir2 plays critical roles in gene silencing, stress resistance and longevity. Mammalian
Sirt1 NAD + -dependent protein deacetylase, the closest homolog of Sir2, regulates cell
cycle, cellular senescence, apoptosis and metabolism, by functional interactions with a ... Cited by 34 - Related articles - All 8 versions
Y Shi, RY Man, PM Vanhoutte - Acta Pharmacologica Sinica, 2008 - chinaphar.com The increased production of oxygen-derived free radicals is an important characteristic of aging
[15,19,20] . Reactive oxygen-derived free radicals not only reduce endothelium-dependent relaxations
by scavenging nitric oxide [21] , but also play a crucial role in endothelium-dependent ... Cited by 9 - Related articles - Cached - BL Direct - All 6 versions
I Sato, I Morita, K Kaji, M Ikeda, M Nagao, S … - Biochemical and …, 1993 - ncbi.nlm.nih.gov To investigate the involvement of nitric oxide (NO) in the pathogenesis of the cardiovascular
system with aging, we studied the basal release of NO in cultured endothelial cells isolated from
normal human umbilical veins (HUVECs) at different population doubling levels (PDLs). ... Cited by 53 - Related articles - BL Direct - All 3 versions
- ►pnas.org T Hayashi, H Matsui-Hirai, A Miyazaki- … - Proceedings of the …, 2006 - National Acad Sciences Senescence may contribute to the pathogenesis of atherosclerosis. Although the bioavailability
of nitric oxide (NO) is limited in senescence, the effect of NO on senescence and its relationship
to cardiovascular risk factors have not been investigated fully. We studied these factors by ... Cited by 26 - Related articles - BL Direct - All 13 versions
T Hayakawa, A Matsuzawa, T Noguchi, K Takeda, H … - Microbes and infection, 2006 - Elsevier The immune system is essential for host defense against a wide range of pathogens. To clear
pathogens, the host must distinguish “non-self” from “self” and then trigger the immune
responses. Recognition of the molecular patterns differentially expressed among ... Cited by 28 - Related articles - All 5 versions
K Watanabe, S Ikeda, J Komatsu, S Inaba, J Suzuki, … - The American journal of …, 2003 - Elsevier We examined the effects of cilostazol on impaired coronary arterial responses in patients with
vasospastic angina (VSA). Thirty patients who were diagnosed with VSA based on an acetylcholine
provocation test and 10 subjects with normal coronary arteries were enrolled. The ... Cited by 13 - Related articles - All 8 versions
- ►physiology.org J Chen, X Huang, D Halicka, S Brodsky, A … - American Journal of …, 2006 - Am Physiological Soc We have previously found that nonenzymatically glycated collagen I (GC), mimicking diabetic
microenvironment, can induce senescent phenotype in early passage human umbilical vein
endothelial cells (HUVECs). In the present study, we explored the functional involvement ... Cited by 15 - Related articles - BL Direct - All 6 versions
