- ►diabetesjournals.org JV Sagen, S Odili, L Bjørkhaug, D Zelent, C Buettger, J … - Diabetes, 2006 - Am Diabetes Assoc Glucokinase functions as a glucose sensor in pancreatic β-cells and regulates hepatic glucose
metabolism. A total of 83 probands were referred for a diagnostic screening of mutations in the
glucokinase (GCK) gene. We found 11 different mutations (V62A, G72R, L146R, A208T, ... Cited by 20 - Related articles - BL Direct - All 5 versions
AL Gloyn, S Odili, D Zelent, C Buettger, HAJ … - Journal of Biological …, 2005 - ASBMB Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK
mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied
the GCK V62M mutation identified in two families and co-segregating with hyperglycemia ... Cited by 31 - Related articles - All 7 versions
- ►diabetesjournals.org D Zelent, ML Golson, B Koeberlein, R Quintens, L Van … - Diabetes, 2006 - Am Diabetes Assoc Enzymatic activity of glucokinase was demonstrated, quantitated, and characterized kinetically
in rat and mouse pituitary extracts using a highly specific and sensitive spectrometric assay. A
previously proposed hypothesis that the glucokinase gene might be expressed in the ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►nih.gov [PDF] CV Burke, CW Buettger, EA Davis, SJ … - Biochemical …, 1999 - pubmedcentral.nih.gov Mutations in the glucokinase (GK) gene cause type-2 maturity- onset diabetes of the young type
2 (MODY-2) and GK- linked hyperinsulinaemia (GK-HI). Recombinant adenoviruses expressing
the human wild-type islet GK or one of four mutant forms of GK, (the MODY-2 mutants ... Cited by 30 - Related articles - BL Direct - All 9 versions
S Baltrusch, S Lenzen, DA Okar, AJ Lange, M … - Journal of Biological …, 2001 - ASBMB The low affinity glucose-phosphorylating enzyme glucokinase shows the phenomenon of intracellular
translocation in beta cells of the pancreas and the liver. To identify potential binding partners
of glucokinase by a systematic strategy, human beta cell glucokinase was screened by a ... Cited by 5 - Related articles - All 2 versions
- ►jbc.org VV Heredia, TJ Carlson, E Garcia, S Sun - Journal of Biological Chemistry, 2006 - ASBMB Glucokinase (GK) has several known polymorphic activating mutations that increase the enzyme
activity by enhancing glucose binding affinity and/or by alleviating the inhibition of glucokinase
regulatory protein (GKRP), a key regulator of GK activity in the liver. Kinetic studies were ... Cited by 13 - Related articles - All 6 versions
M Caüzac, C Kohl, J Girard, JP Pégorier - Biochemical pharmacology, 2005 - Elsevier S-15261 is a new oral anti-hyperglycemic agent that increases insulin sensitivity in various
insulin-resistant animal models. The aim of this study was to determine the short- and long-term
effects of S-15261 and its metabolites (S–15511 and Y-415) on fatty acid and glucose ... Cited by 6 - Related articles - All 3 versions
- ►diabetesjournals.org C Arden, A Trainer, N de la Iglesia, KT Scougall, AL … - Diabetes, 2007 - Am Diabetes Assoc Mutations in the glucokinase (GK) gene cause defects in blood glucose homeostasis. In some
cases (V62M and G72R), the phenotype cannot be explained by altered enzyme kinetics or protein
instability. We used transient and stable expression of green fluorescent protein (GFP) GK ... Cited by 7 - Related articles - BL Direct - All 4 versions
[CITATION] Interaction of PFK-2/FBPase-2 with glucokinase activated glucose phosphorylation …
