CW Lin, YW Lin, FF Yan, J Casey, M Kochhar, EB Pratt, … - Diabetes, 2006 - Am Diabetes Assoc Heterozygous missense mutations in the pore-forming subunit Kir6.2 of ATP-sensitive K + channels
(K ATP channels) have recently been shown to cause permanent neonatal diabetes mellitus
(PNDM). Functional studies demonstrated that PNDM mutations reduce K ATP channel ... Cited by 12 - Related articles - BL Direct - All 5 versions
CW Lin, F Yan, S Shimamura, S Barg, SL Shyng - Diabetes, 2005 - Am Diabetes Assoc ATP-sensitive K + channels (K ATP channels) of pancreatic β-cells play key roles in
glucose-stimulated insulin secretion by linking metabolic signals to cell excitability. Membrane
phosphoinositides, in particular phosphatidylinositol 4,5-bisphosphates (PIP 2 ), stimulate ... Cited by 16 - Related articles - BL Direct - All 6 versions
J Skupien, MT Malecki, W Mlynarski, T … - The Review of …, 2006 - pubmedcentral.nih.gov Activating mutations in the KCNJ11 gene encoding the Kir6.2 subunit of ATP-sensitive potassium
channel have been described in patients with permanent neonatal diabetes mellitus
(PNDM). The main pathophysiological feature of PNDM associated with Kir6.2 mutations ... Cited by 7 - Related articles - All 3 versions
CW Lin, YW Lin, FF Yan, J Casey, M Kochhar, EB Pratt, … - DIABETES, 2006 - Am Diabetes Assoc P ancreatic ATP-sensitive K channels (K ATP chan- nels), each consisting of four pore-forming
Kir6.2 subunits and four regulatory sulfonylurea recep- tor one (SUR1) subunits, link -cell metabolism
to insulin secretion (1–3). The activity of K ATP channels is Related articles
M Suchi, CM MacMullen, PS Thornton, NS Adzick, A … - Modern pathology, 2005 - nature.com Congenital hyperinsulinism is a rare pancreatic endocrine cell disorder that has been categorized
histologically into diffuse and focal forms. In focal hyperinsulinism, the pancreas contains a focus
of endocrine cell adenomatous hyperplasia, and the patients have been reported to ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►jbc.org FF Yan, J Casey, SL Shyng - Journal of Biological Chemistry, 2006 - ASBMB ATP-sensitive potassium (K ATP ) channels mediate glucose-induced insulin secretion by coupling
metabolic signals to -cell membrane potential and the secretory machinery. Reduced K ATP
channel expression caused by mutations in the channel proteins: sulfonylurea receptor 1 ( ... Cited by 13 - Related articles - All 6 versions
- ►diabetesjournals.org FF Yan, YW Lin, C MacMullen, A Ganguly, CA Stanley, … - Diabetes, 2007 - Am Diabetes Assoc Congenital hyperinsulinism (CHI) is a disease characterized by persistent insulin secretion despite
severe hypoglycemia. Mutations in the pancreatic ATP-sensitive K + (K ATP ) channel proteins
sulfonylurea receptor 1 (SUR1) and Kir6.2, encoded by ABCC8 and KCNJ11, ... Cited by 9 - Related articles - BL Direct - All 5 versions
K Yang, K Fang, L Fromondi, KW Chan - FEBS letters, 2005 - Elsevier The pancreatic ATP-sensitive potassium channels comprise two subunits: SUR1 and Kir6.2.
Two SUR1 mutations, A116P and V187D, reduce channel activity causing persistent hyperinsulinemic
hypoglycemia of infancy. We investigated whether these mutations cause temperature ... Cited by 10 - Related articles - All 4 versions
A Fernández-Marmiesse, A Salas, A Vega, JR … - Human …, 2006 - hiperinsulinismo.org 1Unidad de Medicina Molecular,Fundación Pública Galega de Medicina Xenómica,
SERGAS, Hospital Clínico Universitario de Santiago, Galicia, Spain; 2Unidad de Genética, Instituto
de Medicina Legal, Facultae de Medicina, Universidad de Santiago de Compostela, ... Cited by 14 - Related articles - View as HTML - BL Direct - All 3 versions
