DJ Baker, PL Greenhaff, A MacInnes, JA … - Diabetes, 2006 - Am Diabetes Assoc Glycogen phosphorylase inhibition represents a promising strategy to suppress
inappropriate hepatic glucose output, while muscle glycogen is a major source of
fuel during contraction. Glycogen phosphorylase inhibitors (GPi) currently ... Cited by 10 - Related articles - BL Direct - All 7 versions
L Somsak, K Czifrak, M Toth, E Bokor, ED … - Current medicinal chemistry, 2008 - ingentaconnect.com 1 Department of Organic Chemistry, University of Debrecen, POB 20, H-4010
Debrecen, Hungary 2 Institute of Organic & Pharmaceutical Chemistry, The
National Hellenic Research Foundation, 48 Vassileos Constan- tinou Avenue, ... Cited by 3 - Related articles - All 3 versions
DJ Baker, JA Timmons, PL Greenhaff - Diabetes, 2005 - Am Diabetes Assoc Inhibition of hepatic glycogen phosphorylase is a promising treatment strategy
for attenuating hyperglycemia in type 2 diabetes. Crystallographic studies
indicate, however, that selectivity between glycogen phosphorylase in ... Cited by 16 - Related articles - BL Direct - All 5 versions
IR Kelsall, S Munro, I Hallyburton, JL … - FEBS letters, 2007 - Elsevier The inhibition of hepatic glycogen-associated protein phosphatase-1 (PP1-G L )
by glycogen phosphorylase a prevents the dephosphorylation and activation of
glycogen synthase, suppressing glycogen synthesis when glycogenolysis is ... Cited by 8 - Related articles - All 6 versions
PRO Whittamore, MS Addie, SNL Bennett, AM … - Bioorganic & medicinal chemistry letters, 2006 - Elsevier Glycogen phosphorylase (GP) catalyses the breakdown of glycogen to
glucose-1-phosphate. In the liver this is metabolised further to glucose, which
is then secreted into the bloodstream. One approach to reducing ... Cited by 8 - Related articles - All 8 versions
AM Birch, PW Kenny, NG Oikonomakos, L … - Bioorganic & medicinal chemistry letters, 2007 - Elsevier A series of substituted 3,4-dihydro-2-quinolone glycogen phosphorylase
inhibitors, which have potential as antidiabetic agents, is described. Initial
members of the series showed good enzyme inhibitory potency but poor ... Cited by 4 - Related articles - All 7 versions
C Tiraidis, KM Alexacou, SE Zographos, DD … - Protein Science: A Publication of the Protein Society, 2007 - pubmedcentral.nih.gov FR258900 has been discovered as a novel inhibitor of human liver glycogen
phosphorylase a and proved to suppress hepatic glycogen breakdown and reduce
plasma glucose concentrations in diabetic mice models. To elucidate the ... Cited by 4 - Related articles - BL Direct - All 8 versions
- ►physiology.org N Ercan-Fang, MR Taylor, JL Treadway, CB … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc Phosphorylase is regulated by a number of small-molecular-weight effectors that
bind to three sites on the enzyme. Recently, a fourth site referred to as the
indole-inhibitor site has been identified. Synthetic compounds bind to the ... Cited by 4 - Related articles - BL Direct - All 4 versions
- ►jbc.org A Pautsch, N Stadler, O Wissdorf, E Langkopf, … - Journal of Biological Chemistry, 2008 - ASBMB Disrupting the interaction between glycogen phosphorylase and the glycogen
targeting subunit (G L ) of protein phosphatase 1 is emerging as a novel target
for the treatment of type 2 diabetes. To elucidate the molecular basis of ... Cited by 5 - Related articles - All 3 versions
D Zibrova, R Grempler, R Streicher, SG … - The Biochemical journal, 2008 - ncbi.nlm.nih.gov In Type 2 diabetes, increased glycogenolysis contributes to the hyperglycaemic
state, therefore the inhibition of GP (glycogen phosphorylase), a key
glycogenolytic enzyme, is one of the possibilities to lower plasma glucose ... Cited by 6 - Related articles - BL Direct - All 3 versions
