- ►diabetesjournals.org J Ek, SP Hansen, M Lajer, C Nicot, TW … - Diabetes, 2006 - Am Diabetes Assoc Recently, it has been shown that mutations in the P2 promoter of the hepatocyte
nuclear factor (HNF)-4α gene (HNF4A) cause maturity-onset diabetes of the young
(MODY), while single nucleotide polymorphisms in this locus are associated ... Cited by 12 - Related articles - BL Direct - All 6 versions
H Ræder, L Bjørkhaug, S Johansson, K … - Diabetes, 2006 - Am Diabetes Assoc Variants in hepatocyte nuclear factor (HNF)-4α cause maturity-onset diabetes of
the young, type 1 (MODY1) and may also be risk factors for type 2 diabetes. We
sequenced the HNF4A gene of 95 MODY3-negative probands from the Norwegian ... Cited by 19 - Related articles - BL Direct - All 4 versions
LW Harries - Expert Review of Endocrinology and Metabolism, 2006 - ingentaconnect.com Variation in mRNA processing has the capacity to exert fine control over gene
expression in most cell types. The hepatic nuclear factor genes, like
approximately 74% of the genome, produce multiple transcripts. Hepatic ... Cited by 3 - Related articles - All 3 versions
SMS Mitchell, M Vaxillaire, H Thomas, M … - Diabetologia(Berlin), 2002 - cat.inist.fr Aims/hypothesis. The recently identified alternative promoter(P 2) of HNF-4 a is
the major HNF-4 a transcription start site in pancreatic beta cells. The
significance of the P 2 promoter was shown by the identification of a ... Cited by 14 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org CM Damcott, N Hoppman, SH Ott, LJ Reinhart, J … - Diabetes, 2004 - Am Diabetes Assoc Hepatocyte nuclear factor 4-α (HNF4A) is a transcription factor located on
chromosome 20q13 that regulates expression of genes involved in glucose
metabolism and homeostasis. Recently, two groups independently identified ... Cited by 54 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org YL Muller, AM Infante, RL Hanson, L Love- … - Diabetes, 2005 - Am Diabetes Assoc Single nucleotide polymorphisms (SNPs) within the hepatocyte nuclear factor 4α
(HNF4α) gene are associated with type 2 diabetes in Finns and Ashkenazi Jews.
Previous studies in both populations have reported linkage to type 2 ... Cited by 37 - Related articles - BL Direct - All 6 versions
AL Gloyn, S Ellard, M Shepherd, RT Howell, … - Diabetes, 2002 - Am Diabetes Assoc Monogenic human disorders have been used as paradigms for complex genetic
disease and as tools for establishing important insights into mechanisms of gene
regulation and transcriptional control. Maturity-onset diabetes of the ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org K Hara, M Horikoshi, H Kitazato, C Ito, M … - Diabetes, 2006 - Am Diabetes Assoc Hepatocyte nuclear factor (HNF)-4α is a transcription factor known as a key
molecule in the development and functions of the β-cells. In a previously
performed genome-wide scan of Japanese type 2 diabetic sibpairs, we ... Cited by 25 - Related articles - BL Direct - All 5 versions
A Ihara, K Yamagata, T Nammo, A Miura, M … - Biochemical and Biophysical Research …, 2005 - Elsevier Mutations in the hepatocyte nuclear factor (HNF) 4α gene cause a form of
maturity-onset diabetes of the young (MODY1), which is a monogenic form of type
2 diabetes characterized by impaired insulin secretion by pancreatic ... Cited by 15 - Related articles - All 5 versions
SK Hansen, CS Rose, C Glümer, T Drivsholm, … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 452–458 DOI 10.1007/s00125-005-1671-0 ARTICLE SK
Hansen . CS Rose . C. Glümer . T. Drivsholm . K. Borch-Johnsen . ... Cited by 42 - Related articles - All 5 versions
