E Ho, KSL Lam, YS Chen, JCW Yip, M Arvindakshan, … - Diabetes, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during diabetes is thought to be a major cause
of lesions in the peripheral nerves. Here, we used aldose reductase (AR)-deficient (AR −/− )
and AR inhibitor (ARI)-treated mice to further understand the in vivo role of polyol ... Cited by 31 - Related articles - BL Direct - All 7 versions
R Glutathione, I Superoxide - DIABETES, 2006 - Am Diabetes Assoc The exaggerated flux through polyol pathway during dia- betes is thought to be a major cause
of lesions in the peripheral nerves. Here, we used aldose reductase (AR)- deficient (AR / ) and
AR inhibitor (ARI)-treated mice to further understand the in vivo role of polyol pathway in ... Related articles
- ►diabetesjournals.org VR Drel, N Mashtalir, O Ilnytska, J Shin, F Li, VV … - Diabetes, 2006 - Am Diabetes Assoc Whereas functional, metabolic, neurotrophic, and morphological abnormalities of peripheral
diabetic neuropathy (PDN) have been extensively explored in streptozotocin-induced diabetic
rats and mice (models of type 1 diabetes), insufficient information is available on ... Cited by 31 - Related articles - BL Direct - All 7 versions
O Ilnytska, VV Lyzogubov, MJ Stevens, VR Drel, N … - Diabetes, 2006 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation is emerging as a fundamental mechanism in
the pathogenesis of diabetes complications including diabetic neuropathy. This study evaluated
the role of PARP in diabetic sensory neuropathy. The experiments were performed in ... Cited by 28 - Related articles - BL Direct - All 10 versions
IG Obrosova, VR Drel, P Pacher, O Ilnytska, ZQ Wang, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of diabetes
complications, is considered a downstream effector of oxidative-nitrosative stress. However,
some recent findings suggest that it is not necessarily the case and that PARP activation ... Cited by 38 - Related articles - BL Direct - All 11 versions
- ►oxfordjournals.org S Yagihashi, SI Yamagishi, R Wada, M Baba, TC … - Brain, 2001 - Oxford Univ Press The present study was designed to examine the effect of aldose reductase (AR) overexpression
on the development of diabetic neuropathy by using mice transgenic for human AR. At 8 weeks
of age, transgenic mice (Tg) and non-transgenic littermates (Lm) were made diabetic with ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►academia.edu [PDF] I Vareniuk, IA Pavlov, VR Drel, VV Lyzogubov, O … - Experimental Neurology, 2007 - Elsevier Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired
nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species
in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the ... Cited by 19 - Related articles - All 5 versions
- ►umich.edu [PDF] AP Kellogg, R Pop-Busui - Antioxidants & Redox Signaling, 2005 - liebertonline.com D IABETIC PERIPHERAL NEUROPATHY (DPN) affects most patients with diabetes and is the
leading cause of non- traumatic lower limb amputations, accounting for 85,000 amputations per
year in the US To date, besides a tight glycemic control, a viable treatment for human ... Cited by 18 - Related articles - BL Direct - All 4 versions
- ►physiology.org CL Oltman, LJ Coppey, JS Gellett, EP … - American Journal of …, 2005 - Am Physiological Soc We have examined the progression of vascular and neural deficits in Zucker rats, Zucker diabetic
fatty (ZDF) diabetic rats, and age-matched lean ZDF rats from 8 to 40 wk of age. Both the ZDF
diabetic and Zucker rats were glucose intolerant at 8 wk of age. The Zucker rats did not ... Cited by 28 - Related articles - BL Direct - All 4 versions
