- ►shouxi.net JM Jasinski, L Yu, M Nakayama, MM Li, MA … - Diabetes, 2006 - Am Diabetes Assoc A series of recent studies in humans and the NOD mouse model have highlighted
the central role that autoimmunity directed against insulin, in particular the
insulin B chain 9-23 peptide, may play in the pathogenesis of type 1 ... Cited by 17 - Related articles - BL Direct - All 5 versions
- ►nih.gov W Du, FS Wong, MO Li, J Peng, H Qi, RA … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig We have previously isolated insulin-reactive Tregs from diabetic NOD mice
designated 2H6, from which TCR transgenic mice were generated. The T cells from
these 2H6 transgenic mice recognize insulin but have suppressive properties ... Cited by 23 - Related articles - BL Direct - All 8 versions
- ►nih.gov M Nakayama, JN Beilke, JM Jasinski, M … - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig NOD mice with knockout of both native insulin genes and a mutated proinsulin
transgene, alanine at position B16 in preproinsulin (B16:A-dKO mice), do not
develop diabetes. Transplantation of NOD islets, but not bone marrow, ... Cited by 15 - Related articles - BL Direct - All 6 versions
E Jaeckel, MA Lipes, H von Boehmer - Insulin (pmol/l) - microbio.uab.edu Although autoimmune diseases can be initiated by immunization with a single
antigen, it is not clear whether a single self antigen is essential for the
initiation and, perhaps, the perpetuation of spontaneous autoimmunity. Some ... Cited by 55 - Related articles - BL Direct - All 7 versions
JM Jasinski, GS Eisenbarth - Clinical & Developmental Immunology, 2005 - hindawi.com Page 1. Insulin as a primary autoantigen for type 1A diabetes JM JASINSKI
1,2,† , & GS EISENBARTH 2,3 1 Human Medical Genetics ... Cited by 15 - Related articles - View as HTML - BL Direct - All 10 versions
EA Simone, L Yu, DR Wegmann, GS … - Journal of Autoimmunity, 1997 - Elsevier The great majority of insulin-specific T cell clones isolated from islets of NOD
mice react with insulin peptide B-(9–23) (amino acids 9–23 of the insulin B
chain). The T cell receptors of these clones contain diverse β-chains but ... Cited by 9 - Related articles - BL Direct - All 3 versions
- ►nih.gov H Moriyama, N Abiru, J Paronen, K Sikora, E … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences It has been reported that an insulin 2 gene knockout, when bred onto nonobese
diabetic (NOD) mice, accelerates diabetes. We produced insulin 1 gene knockout
congenic NOD mice. In contrast to insulin 2, diabetes and insulitis were ... Cited by 79 - Related articles - BL Direct - All 10 versions
- ►jimmunol.org P Halbout, JP Briand, C Becourt, S Muller, C … - The Journal of Immunology, 2002 - Am Assoc Immnol Immunization against insulin, insulin B chain, or B chain peptide B 9–23
(preproinsulin peptide II 33–47 ) prevents diabetes in the nonobese diabetic
(NOD) mouse. Whether or not peptide II 33–47 is the only proinsulin ... Cited by 27 - Related articles - BL Direct - All 4 versions
- ►nih.gov B Krishnamurthy, NL Dudek, MD McKenzie, AW … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig 1 St. Vincent's Institute, Fitzroy, Victoria, Australia. 2 Department of
Biochemistry and Molecular Biology, Bio21 Institute, and 3 Department of
Microbiology and Immunology, The University of Melbourne, Parkville, ... Cited by 36 - Related articles - BL Direct - All 10 versions
J Holst, AL Szymczak-Workman, KM Vignali, … - Nature Protocols, 2006 - nature.com T-cell receptor (TCR) transgenic (Tg) mice have revolutionized our understanding
of many aspects of T-cell biology. Whereas they provide an almost unlimited
source of T cells with a single specificity, breeding them onto different ... Cited by 22 - Related articles - BL Direct - All 3 versions
