- ►shouxi.net P Alard, JN Manirarora, SA Parnell, JL … - Diabetes, 2006 - Am Diabetes Assoc Various defects in antigen-presenting cells (APCs) and T-cells, including
regulatory cells, have been associated with type 1 diabetes development in NOD
mice. CD4 + CD25 + regulatory cells play a crucial role in controlling ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Feuerer, W Jiang, PD Holler, A Satpathy, C … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences FoxP3 + CD4 + regulatory T cells (Tregs) play a key role in the maintenance of
peripheral self-tolerance, and it has been suggested that diabetes-susceptible
nonobese diabetic (NOD) mice are defective in the generation and numbers of ... Cited by 16 - Related articles - BL Direct - All 9 versions
RJ Mellanby, D Thomas, JM Phillips, A Cooke - Immunology, 2007 - pubmedcentral.nih.gov The role of regulatory T cells (Tregs) in maintaining self tolerance has been
intensively researched and there is a growing consensus that a decline in Treg
function is an important step towards the development of autoimmune ... Cited by 27 - Related articles - BL Direct - All 7 versions
- ►shouxi.net S You, M Belghith, S Cobbold, MA Alyanakian … - Diabetes, 2005 - Am Diabetes Assoc Diabetogenic T-cells can be detected in pre-diabetic nonobese diabetic (NOD)
mice after transfer in NOD-SCID recipients. Here we demonstrate that 6-week-old
pre-diabetic NOD mice, >2 months before disease onset, already harbor ... Cited by 95 - Related articles - All 5 versions
- ►diabetesjournals.org M Tritt, E Sgouroudis, E d'Hennezel, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—We show that the cellular frequency of Foxp3 + nT reg cells in primary
and secondary lymphoid tissues is stable and does not decline relative to type 1
diabetes–resistant mice. We show that thymic and peripheral CD4 + CD25 + ... Cited by 33 - Related articles - BL Direct - All 5 versions
- ►nih.gov AJ Wu, H Hua, SH Munson, HO McDevitt - Proceedings of the National Academy of Sciences of …, 2002 - National Acad Sciences The mechanism by which tumor necrosis factor-α (TNF) differentially modulates
type I diabetes mellitus in the nonobese diabetic (NOD) mouse is not well
understood. CD4 + CD25 + T cells have been implicated as mediators of self- ... Cited by 144 - Related articles - BL Direct - All 10 versions
JN Manirarora, MM Kosiewicz, SA Parnell, P … - PLoS ONE, 2008 - pubmedcentral.nih.gov To test these hypotheses, we used the well-documented ability of complete
Freund's adjuvant (CFA), an APC activator, to prevent disease in NOD mice.
Phenotype and function of CD4 CD25 regulatory cells from untreated and CFA- ... Cited by 2 - Related articles - All 5 versions
JN Manirarora, MM Kosiewicz, SA Parnell, P … - immuno.grad.uiowa.edu Methodology/Principal Findings: To test these hypotheses, we used the
well-documented ability of complete Freund's adjuvant (CFA), an APC activator,
to prevent disease in NOD mice. Phenotype and function of CD4+CD25+ ... Cited by 1 - Related articles - View as HTML
- ►jimmunol.org E Dahlen, G Hedlund, K Dawe - The Journal of Immunology, 2000 - Am Assoc Immnol The nonobese diabetic (NOD) mouse spontaneously develops autoimmune
insulin-dependent diabetes mellitus and serves as a model for human type I
diabetes. NOD spleen cells proliferate to a lesser extent than those from ... Cited by 80 - Related articles - BL Direct - All 2 versions
- ►rupress.org SM Pop, CP Wong, DA Culton, SH Clarke, R … - Journal of Experimental Medicine, 2005 - jem.rupress.org Natural CD4 + CD25 + regulatory T (CD4 + CD25 + T reg) cells play a key role in
the immunoregulation of autoimmunity. However, little is known about the
interactions between CD4 + CD25 + T reg cells and autoreactive T cells. ... Cited by 110 - Related articles - All 8 versions
