- ►diabetesjournals.org AV Matveyenko, PC Butler - Diabetes, 2006 - Am Diabetes Assoc Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an ∼50 and 65% deficit in β-cell mass, with increased ... Cited by 39 - Related articles - BL Direct - All 4 versions
中华临床医师杂志征稿， 五届中华脊柱医学论坛 … - journal.shouxi.net Type 2 diabetes is characterized by defects in insulin secretion and action and
is preceded by impaired fasting glucose (IFG). The islet anatomy in IFG and type
2 diabetes reveals an 50 and 65% deficit in -cell mass, with increased ... Related articles - Cached
AV Matveyenko, PC Butler - ILAR JOURNAL, 2006 - dels.nas.edu Blood glucose concentrations are maintained by insulin se- creted from ß-cells
located in the islets of Langerhans. There are ∼2000 ß-cells per islet, and
∼one million islets of Langerhans scattered throughout the pancreas. The ... Cited by 15 - Related articles - View as HTML - BL Direct - All 2 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►escholarship.org AE Butler, J Jang, T Gurlo, MD Carty, WC … - Diabetes, 2004 - Am Diabetes Assoc The islet in type 2 diabetes is characterized by a deficit in β-cell mass,
increased β-cell apoptosis, and impaired insulin secretion. Also, islets in
type 2 diabetes often contain deposits of islet amyloid derived from islet ... Cited by 93 - Related articles - BL Direct - All 9 versions
- ►cdlib.org [PDF] - Free from Publisher RA Ritzel, AE Butler, RA Rizza, JD Veldhuis, … - Diabetes Care, 2006 - Am Diabetes Assoc In type 2 diabetes there is a progressive defect of insulin secretion that
precedes the development of hyperglycemia (1). This defect appears to be at
least in part due to a deficit in β-cell mass (2–4). Several therapeutic ... Cited by 41 - Related articles - BL Direct - All 9 versions
B Konarkowska, JF Aitken, J Kistler, S Zhang … - FEBS J, 2006 - interscience.wiley.com Human amylin is a small fibrillogenic protein that is the major constituent of
pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes.
There is evidence that it can elicit in vitro apoptosis in islet β-cells, ... Cited by 34 - Related articles - BL Direct - All 4 versions
- ►endojournals.org L Haataja, T Gurlo, CJ Huang, PC Butler - Endocrine Reviews, 2008 - Endocrine Soc Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin
secretion, loss of β-cell mass with increased β-cell apoptosis and islet
amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, ... Cited by 28 - Related articles - BL Direct - All 4 versions
JJ Meier, AE Butler, R Galasso, RA Rizza, PC … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Type 1 and type 2 diabetes are charac- terised by a
beta cell deficit. Islet hyperplasia has been described in patients with
Zollinger–Ellison syndrome secondary to gastrin-producing tumours ... Cited by 21 - Related articles - BL Direct - All 5 versions
