R Dentin, F Benhamed, I Hainault, V Fauveau, … - Diabetes, 2006 - Am Diabetes Assoc Obesity is a metabolic disorder often associated with type 2 diabetes, insulin
resistance, and hepatic steatosis. Leptin-deficient (ob/ob) mice are a
well-characterized mouse model of obesity in which increased hepatic ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►cell.com K Uyeda, JJ Repa - Cell Metabolism, 2006 - Elsevier The ability of an organism to sense and store nutrients is vital to survival.
The liver is the major organ responsible for converting excess dietary
carbohydrate to lipid for storage. An elegant molecular pathway has evolved ... Cited by 57 - Related articles - All 7 versions
- ►physiology.org [PDF] K Iizuka, B Miller, K Uyeda - American Journal of Physiology- Endocrinology And …, 2006 - Am Physiological Soc 28 articles, 16 of which you can access free at: This article cites
http://ajpendo.physiology.org/cgi/content/full/291/2/E358#BIBL ... 1 other
HighWire hosted article: This article has been cited by Cited by 27 - Related articles - BL Direct - All 4 versions
- ►nih.gov [PDF] K Iizuka, RK Bruick, G Liang, JD Horton, K … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences The liver provides for long-term energy needs of the body by converting excess
carbohydrate into fat for storage. Insulin is one factor that promotes hepatic
lipogenesis, but there is increasing evidence that glucose also contributes ... Cited by 147 - Related articles - BL Direct - All 16 versions
S Ishii, K IIzuka, BC Miller, K Uyeda - Proceedings of the National Academy of Sciences of …, 2004 - National Acad Sciences Carbohydrate response element (ChRE)-binding protein (ChREBP) is a recently
discovered transcription factor that is activated in response to high glucose
concentrations in liver independently of insulin. ChREBP was first ... Cited by 121 - Related articles - BL Direct - All 10 versions
- ►nih.gov R Dentin, F Benhamed, JP Pégorier, F Foufelle, … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Dietary polyunsaturated fatty acids (PUFAs) are potent inhibitors of hepatic
glycolysis and lipogenesis. Recently, carbohydrate-responsive element–binding
protein (ChREBP) was implicated in the regulation by glucose of glycolytic ... Cited by 73 - Related articles - BL Direct - All 13 versions
MV Li, B Chang, M Imamura, N Poungvarin, L … - Diabetes, 2006 - Am Diabetes Assoc We report here a novel mechanism for glucose-mediated activation of carbohydrate
response element binding protein (ChREBP), a basic helix-loop-helix/leucine
zipper (bHLH/ZIP) transcription factor of Mondo family that binds to ... Cited by 34 - Related articles - BL Direct - All 5 versions
L Ma, LN Robinson, HC Towle - Journal of Biological Chemistry, 2006 - ASBMB In mammals, glucose-regulated gene expression has been best characterized in the
liver, where increased glucose metabolism induces transcription of genes
encoding enzymes involved in de novo lipogenesis. ChREBP and Mlx dimerize ... Cited by 42 - Related articles - All 6 versions
PD Denechaud, P Bossard, JMA Lobaccaro, L … - The Journal of Clinical Investigation, 2008 - pubmedcentral.nih.gov The transcription factor carbohydrate-responsive element–binding protein
(ChREBP) has emerged as a central regulator of lipid synthesis in liver because
it is required for glucose-induced expression of the glycolytic enzyme ... Cited by 32 - Related articles - BL Direct - All 6 versions
- ►cell.com M Monetti, MC Levin, MJ Watt, MP Sajan, S … - Cell metabolism, 2007 - Elsevier Hepatic steatosis, the accumulation of lipids in the liver, is widely believed
to result in insulin resistance. To test the causal relationship between hepatic
steatosis and insulin resistance, we generated mice that overexpress ... Cited by 57 - Related articles - All 8 versions
