M Zang, S Xu, KA Maitland-Toolan, A Zuccollo, X Hou, … - Diabetes, 2006 - Am Diabetes Assoc Because polyphenols may have beneficial effects on dyslipidemia, which accelerates atherosclerosis
in diabetes, we examined the effect of polyphenols on hepatocellular AMP-activated protein
kinase (AMPK) activity and lipid levels, as well as hyperlipidemia and atherogenesis in ... Cited by 89 - Related articles - BL Direct - All 5 versions
X Hou, S Xu, KA Maitland-Toolan, K Sato, B Jiang, … - Journal of Biological …, 2008 - ASBMB Resveratrol may protect against metabolic disease through activating SIRT1 deacetylase. Because
we have recently defined AMPK activation as a key mechanism for the beneficial effects of polyphenols
on hepatic lipid accumulation, hyperlipidemia, and atherosclerosis in type 1 diabetic ... Cited by 45 - Related articles - All 4 versions
B Dasgupta, J Milbrandt - … of the National Academy of Sciences, 2007 - National Acad Sciences Resveratrol is a polyphenol produced by plants that has multiple beneficial activities similar to
those associated with caloric restriction (CR), such as increased life span and delay in the onset
of diseases associated with aging. CR improves neuronal health, and the global ... Cited by 91 - Related articles - BL Direct - All 8 versions
CE Park, MJ Kim, JH Lee, BI Min, H Bae, W … - … & molecular medicine, 2007 - ncbi.nlm.nih.gov 1: Exp Mol Med. 2007 Apr 30;39(2):222-9. Resveratrol stimulates glucose transport
in C2C12 myotubes by activating AMP-activated protein kinase. Park CE, Kim MJ,
Lee JH, Min BI, Bae H, Choe W, Kim SS, Ha J. Department ... Cited by 27 - Related articles - BL Direct - All 11 versions
M Zang, A Zuccollo, X Hou, D Nagata, K Walsh, H … - Journal of Biological …, 2004 - ASBMB The antidiabetic drug metformin stimulates AMP-activated protein kinase (AMPK) activity in the
liver and in skeletal muscle. To better understand the role of AMPK in the regulation of hepatic
lipids, we studied the effect of metformin on AMPK and its downstream effector, ... Cited by 94 - Related articles - BL Direct - All 4 versions
- ►cell.com C Sun, F Zhang, X Ge, T Yan, X Chen, X Shi, Q Zhai - Cell metabolism, 2007 - Elsevier Insulin resistance is often characterized as the most critical factor contributing to the development
of type 2 diabetes. SIRT1 has been reported to be involved in the processes of glucose metabolism
and insulin secretion. However, whether SIRT1 is directly involved in insulin sensitivity is ... Cited by 78 - Related articles - All 7 versions
AYM Chan, VW Dolinsky, CLM Soltys, B Viollet, S … - Journal of Biological …, 2008 - ASBMB Whereas studies involving animal models of cardiovascular disease demonstrated that resveratrol
is able to inhibit hypertrophic growth, the mechanisms involved have not been elucidated. Because
studies in cells other than cardiomyocytes revealed that AMP-activated protein kinase ( ... Cited by 23 - Related articles - All 3 versions
B Cool, B Zinker, W Chiou, L Kifle, N Cao, M Perham, R … - Cell metabolism, 2006 - Elsevier AMP-activated protein kinase (AMPK) is a key sensor and regulator of intracellular and
whole-body energy metabolism. We have identified a thienopyridone family of AMPK
activators. A-769662 directly stimulated partially purified rat liver AMPK (EC 50 = 0.8 μM) ... Cited by 91 - Related articles - All 9 versions
S Fröjdö, D Cozzone, H Vidal, L Pirola - The Biochemical Journal, 2007 - pubmedcentral.nih.gov Resveratrol, a polyphenol found in fruits, possesses chemopreventive and chemotherapeutic
properties and has been shown to increase lifespan in yeast and metazoans, including
mice. Genetic evidence and in vitro enzymatic measurements indicate that the ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►pbrc.edu [PDF] JA Baur, KJ Pearson, NL Price, HA Jamieson, C Lerin, … - Nature, 2006 - nature.com Resveratrol (3,5,4'-trihydroxystilbene) extends the lifespan of diverse species including Saccharomyces
cerevisiae, Caenorhabditis elegans and Drosophila melanogaster. In these organisms, lifespan
extension is dependent on Sir2, a conserved deacetylase proposed to underlie the ... Cited by 620 - Related articles - BL Direct - All 34 versions
