E Estella, MD McKenzie, T Catterall, VR … - Diabetes, 2006 - Am Diabetes Assoc Perforin-deficient NOD mice are protected from diabetes, suggesting that
cytotoxic granule contents of CD8 + T-cells have a significant role in killing
β-cells. Despite this, cytotoxic granule effects on human or mouse ... Cited by 13 - Related articles - BL Direct - All 4 versions
E Estella, MD McKenzie, T Catterall, VR … - 糖尿病学杂志, 2006 - journal.shouxi.net Perforin-deficient NOD mice are protected from diabetes, suggesting that
cytotoxic granule contents of CD8+ T-cells have a significant role in killing
-cells. Despite this, cytotoxic granule effects on human or mouse ... Related articles - Cached
VR Sutton, E Estella, C Li, M Chen, HE … - Transplantation, 2006 - journals.lww.com Skip Navigation Links Home > January 27, 2006 - Volume 81 - Issue 2 > A Critical
Role for Granzyme B, in Addition to Perforin and... ... Sutton, Vivien R.;
Estella, Eugene; Li, Chi; Chen, Melanie; Thomas, Helen E.; Kay, Thomas W.; ... Cited by 13 - Related articles - BL Direct - All 3 versions
PD Campbell, E Estella, NL Dudek, G Jhala, … - Human Immunology, 2008 - Elsevier Cytotoxic T lymphocytes (CTL) are believed to play an essential role in β-cell
destruction leading to development of type 1 diabetes and allogeneic islet graft
failure. We aimed to identify the mechanisms used by CTL to kill human β ... Cited by 1 - Related articles - All 2 versions
HE Thomas, MD McKenzie, E Angstetra, PD … - Apoptosis - Springer Abstract Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes
as well as loss of islets after trans- plantation. In type 1 diabetes, beta
cells are destroyed by immunological mechanisms. In type 2 diabetes ... Cited by 1 - Related articles - All 2 versions
H Fujinaka, T Yamamoto, L Feng, M Nameta, G … - Kidney International, 2007 - nature.com The depletion of CD8 + cells has been shown to prevent the initiation and
progression of antiglomerular basement membrane (GBM) crescentic
glomerulonephritis (GN) in Wistar–Kyoto (WKY) rats. In this study, we ... Cited by 2 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org MD McKenzie, EM Carrington, T Kaufmann, A … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Development and function of islets were not affected by loss of Bid,
and Bid-deficient islets were as susceptible as wild-type islets to cytotoxic
stimuli that cause apoptosis via the mitochondrial pathway. In contrast, ... Cited by 11 - Related articles - BL Direct - All 3 versions
- ►shouxi.net NL Dudek, HE Thomas, L Mariana, RM … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-cells are the major mediators of β-cell destruction in type 1
diabetes, but the molecular mechanisms are not definitively established. We have
examined the contribution of perforin and Fas ligand to β-cell destruction ... Cited by 19 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org MD McKenzie, NL Dudek, L Mariana, MMW … - International immunology, 2006 - Jpn Soc Immunol Direct interaction between auto-reactive CTL and specific peptide–MHC class I
complexes on pancreatic beta cells is critical in mediating beta cell
destruction in type I diabetes. We used mice with genetic modifications in ... Cited by 19 - Related articles - All 4 versions
- ►diabetesjournals.org N Liadis, L Salmena, E Kwan, P Tajmir, SA … - Diabetes, 2007 - Am Diabetes Assoc Inadequate pancreatic β-cell mass resulting from excessive β-cell apoptosis is
a key defect in type 1 and type 2 diabetes. Caspases are the major molecules
involved in apoptosis; however, in vivo roles of specific caspases in ... Cited by 5 - Related articles - BL Direct - All 4 versions
