- ►diabetesjournals.org XL Wang, L Zhang, K Youker, MX Zhang, J Wang, SA … - Diabetes, 2006 - Am Diabetes Assoc In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation
of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which
are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic ... Cited by 49 - Related articles - BL Direct - All 4 versions
XL Wang, L Zhang, K Youker, MX Zhang, J Wang, SA … - 糖尿病学杂志, 2006 - journal.shouxi.net In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation
of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which
are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic ... Related articles - Cached
- ►jbc.org YH Shen, L Zhang, Y Gan, X Wang, J Wang, SA … - Journal of Biological …, 2006 - ASBMB The key feature of metabolic syndrome, a cluster of metabolic and cardiovascular disorders,
is systemic insulin resistance, which is associated with dysregulated endothelial nitric-oxide
synthase (eNOS). Stress signaling induced by inflammation can inhibit insulin signaling. ... Cited by 45 - Related articles - BL Direct - All 8 versions
- ►jbc.org HY Liu, QF Collins, Y Xiong, F Moukdar, EG Lupo Jr … - Journal of Biological …, 2007 - ASBMB Free fatty acid (FFA) is believed to be a major environmental factor linking obesity to Type II
diabetes. We have recently reported that FFA can induce gluconeogenesis in hepatocytes through
p38 mitogen-activated protein kinase (p38). In this study, we have investigated the role of ... Cited by 28 - Related articles - All 6 versions
- ►ahajournals.org F Kim, KA Tysseling, J Rice, M Pham, L Haji, … - … , and vascular biology, 2005 - Am Heart Assoc Methods and Results— We demonstrate that insulin-mediated tyrosine phosphorylation of
IRS-1 and serine phosphorylation of Akt, eNOS, and NO production are significantly inhibited
by treatment of bovine aortic endothelial cells with 100 µmol/L FFA composed of palmitic ... Cited by 89 - Related articles - All 8 versions
- ►ebmonline.org S Maeda, S Jesmin, M Iemitsu, T Otsuki, T Matsuo, K … - Experimental Biology and …, 2006 - SEBM Obesity is associated with endothelial dysfunction that may contribute to the development of
diabetes, hypertension, and atherosclerosis. Endothelin-1 (ET-1), which is produced mostly by
vascular endothelial cells, has potent vasoconstrictor and proliferative activity in vascular ... Cited by 10 - Related articles - BL Direct - All 3 versions
QF Collins, Y Xiong, EG Lupo, HY Liu, W Cao - Journal of Biological Chemistry, 2006 - ASBMB Free fatty acids (FFA) are considered as a causative link between obesity and diabetes. In various
animal models and in humans FFA can stimulate hepatic gluconeogenesis. Although the in vivo
role of FFA in hepatic gluconeogenesis has been clearly established, the intracellular role ... Cited by 38 - Related articles - All 6 versions
- ►endojournals.org R Muniyappa, M Montagnani, KK Koh, MJ Quon - Endocrine reviews, 2007 - Endocrine Soc Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and subsequent
augmentation of glucose disposal in classical insulin target tissues (e.g., skeletal muscle). ... Cited by 101 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org EC Eringa, CDA Stehouwer, K Walburg, AD … - … , and vascular biology, 2006 - Am Heart Assoc Methods and Results— Insulin-mediated vasoreactivity of isolated resistance arteries of the rat
cremaster muscle to insulin (4 to 3400 µU/mL) was studied in the absence and presence of
TNF- (10 ng/mL). Although insulin or TNF- alone did not affect arterial diameter, insulin ... Cited by 30 - Related articles - All 9 versions
R Arita, Y Hata, S Nakao, T Kita, M Miura, S Kawahara, … - Diabetes, 2009 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Localization of RhoA/ROCK and Rho activity were examined
in retinal tissues of rats. Impact of intravitreal fasudil administration on retinal endothelial nitric
oxide synthase (eNOS) and myosin phosphatase target protein (MYPT)-1 ... Cited by 7 - Related articles - All 4 versions
