A Salehi, E Vieira, E Gylfe - Diabetes, 2006 - Am Diabetes Assoc Hypersecretion of glucagon contributes to the dysregulation of glucose homeostasis in
diabetes. To clarify the underlying mechanism, glucose-regulated glucagon secretion was studied
in mouse pancreatic islets and clonal hamster In-R1-G9 glucagon-releasing cells. Apart ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►endojournals.org HL Olsen, S Theander, K Bokvist, K Buschard, CB … - Endocrinology, 2005 - Endocrine Soc In isolated rat pancreatic -cells, glucose, arginine, and the sulfonylurea tolbutamide stimulated
glucagon release. The effect of glucose was abolished by the K ATP -channel opener diazoxide
as well as by mannoheptulose and azide, inhibitors of glycolysis and mitochondrial ... Cited by 43 - Related articles - BL Direct - All 5 versions
YM Leung, I Ahmed, L Sheu, RG Tsushima, NE … - … and Biophysical Research …, 2006 - Elsevier In low or absence of glucose, α-cells generate rhythmic action potentials and secrete
glucagon. α-Cell T-type Ca 2+ channels are believed to be pacemaker channels, which are expected
to open near the resting membrane potential (around −60 mV) to initiate a small ... Cited by 9 - Related articles - All 5 versions
S Vignali, V Leiss, R Karl, F Hofmann, A … - The Journal of …, 2006 - Physiological Soc Insulin and glucagon are the major hormones of the islets of Langerhans that are stored and
released from the B- and A-cells, respectively. Both hormones are secreted when the intracellular
cytosolic Ca 2+ concentration ([Ca 2+ ] i ) increases. The [Ca 2+ ] i is modulated by mutual ... Cited by 18 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org CS Olofsson, A Salehi, SO Göpel, C Holm, P Rorsman - Diabetes, 2004 - Am Diabetes Assoc We have investigated the short-term effects of the saturated free fatty acid (FFA) palmitate on
pancreatic -cells. Palmitate (0.5 or 1 mmol/l bound to fatty acid–free albumin) stimulated glucagon
secretion from intact mouse islets 1.5- to 2-fold when added in the presence of 1–15 ... Cited by 22 - Related articles - BL Direct - All 4 versions
E Vieira, A Salehi, E Gylfe - Diabetologia, 2007 - Springer Abstract Aims/hypothesis The mechanisms by which glucose regu- lates glucagon release are
poorly understood. The present study aimed to clarify the direct effects of glucose on the
glucagon-releasing alpha cells and those effects mediated by paracrine islet factors. ... Cited by 24 - Related articles - BL Direct - All 4 versions
- ►cell.com E Xu, M Kumar, Y Zhang, W Ju, T Obata, N Zhang, S … - Cell Metabolism, 2006 - Elsevier Excessive secretion of glucagon is a major contributor to the development of diabetic
hyperglycemia. Secretion of glucagon is regulated by various nutrients, with glucose being a
primary determinant of the rate of α cell glucagon secretion. The intra-islet action of ... Cited by 30 - Related articles - All 9 versions
A Munoz, M Hu, K Hussain, J Bryan, L Aguilar-Bryan, … - Endocrinology, 2005 - Endocrine Soc Glucagon is a potent counterregulatory hormone that opposes the action of insulin in controlling
glycemia. The cellular mechanisms by which pancreatic -cell glucagon secretion occurs in response
to hypoglycemia are poorly known. SUR1/K IR 6.2-type ATP-sensitive K + (K ATP ) ... Cited by 20 - Related articles - BL Direct - All 5 versions
YJ Liu, E Vieira, E Gylfe - Cell Calcium, 2004 - Elsevier The glucagon-releasing pancreatic α-cells are electrically excitable cells but the signal transduction
leading to depolarization and secretion is not well understood. To clarify the mechanisms we
studied [Ca 2+ ] i and membrane potential in individual mouse pancreatic α-cells using ... Cited by 38 - Related articles - All 3 versions
SJ Bailey, MA Ravier, GA Rutter - Diabetes, 2007 - Am Diabetes Assoc The mechanism(s) by which glucose regulates glucagon secretion both acutely and in the longer
term remain unclear. Added to isolated mouse islets in the presence of 0.5 mmol/l glucose,
γ-aminobutyric acid (GABA) inhibited glucagon release to a similar extent (46%) as 10 ... Cited by 10 - Related articles - BL Direct - All 7 versions
