- ►diabetesjournals.org T Saukkonen, F Shojaee-Moradie, RM Williams, R … - Diabetes, 2006 - Am Diabetes Assoc Recombinant human IGF-I (rhIGF-I) complexed with its natural binding protein IGF-binding protein
(IGFBP)-3 (rhIGF-I/IGFBP-3) is a novel formulation that has been shown to improve insulin sensitivity
in type 1 diabetes, yet the mechanisms are not clear. We used stable isotopes to ... Cited by 14 - Related articles - BL Direct - All 6 versions
RM Williams, A McDonald, M O'Savage, … - Expert Opin. Drug …, 2008 - informahealthcare.com Background: Mecasermin rinfabate (iPLEX ™ ), comprising rhIGF-I complexed to rhIGFBP-3,
was developed in an attempt to prolong the half-life of IGF-I and potentially reduce side
effects. It is administered as a once-daily subcutaneous injection. Treatment with rhIGF-I ... Cited by 7 - Related articles - BL Direct - All 6 versions
- ►endojournals.org T Saukkonen, R Amin, RM Williams, C Fox, KC … - Journal of Clinical …, 2004 - Endocrine Soc GH hypersecretion in type 1 diabetes has been implicated in the pathogenesis of insulin
resistance, and microangiopathic complications, and may result from reduced circulating IGF
levels. We examined the effects of recombinant human (rh)IGF-I [complexed in equimolar ... Cited by 33 - Related articles - BL Direct - All 4 versions
U Berg, T Gustafsson, CJ Sundberg, C Carlsson- … - Growth Hormone & IGF …, 2006 - Elsevier IGF-I plays a direct role in whole body glucose homeostasis primarily by stimulating skeletal
muscle glucose uptake. IGF-I is also involved in exercise induced muscle hypertrophy. Knowledge
regarding local changes in muscle IGF-I bioavailability and its regulation by IGFBPs at ... Cited by 7 - Related articles - All 3 versions
S Pihl, C Carlsson-Skwirut, U Berg, K Ekstrom, P Bang - Horm Res, 2006 - content.karger.com Human conditions of elevated interleukin-6 (IL-6) and transgenic mice overexpressing IL-6 have
increased proteolytic degradation of insulin-like growth factor binding protein (IGFBP)-3. In
addition, IL-6 alters the hepatic expression of insulin-like growth factor-I (IGF-I) and the ... Cited by 9 - Related articles - BL Direct - All 5 versions
I Zachrisson, K Brismar, C Carlsson-Skwirut, G … - Growth Hormone & IGF …, 2000 - Elsevier Hyperglycaemia and increased variability of blood glucose in pubertal children with type 1 diabetes
may be related to increased growth hormone (GH) secretion and insulin resistance. The role
of changes in insulin-like growth factor-I (IGF-I) bioavailability for the glycaemic control in ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►endojournals.org DR Clemmons, M Sleevi, G Allan, A … - Journal of Clinical …, 2007 - Endocrine Soc Results: Fasting glucose was reduced in the groups that received either 1 (32 ± 5%
reduction) or 2 mg/kg·d (40 ± 6% reduction) of the complex. Mean daily glucose (four
determinations) was reduced by 26 ± 4% in the 1 mg/kg group and by 33 ± 5% in the 2 ... Cited by 10 - Related articles - BL Direct - All 3 versions
N Hirota, S Otabe, H Nakayama, X Yuan, K Yamada - Life sciences, 2006 - Elsevier To assess the mechanism of β-cell lipotoxicity in comparison with Fas-mediated cell death, we
used a mouse β-cell clone stably transfected with human Fas. Palmitate induced β-cell death
in correlation with medium glucose levels between 5 and 20 mmol/l, while Fas-mediated ... Cited by 3 - Related articles - All 4 versions
H Thisted, SP Johnsen, J Rungby - Basic & Clinical …, 2006 - interscience.wiley.com Abstract: For both type 1 and type 2 diabetes, tight glycaemic control is vital to reduce the risk
of long-term complications. However, this must be achieved with minimal risk of
hypoglycaemia. Glargine is a new long-acting insulin analogue with an action profile ... Cited by 14 - Related articles - BL Direct - All 6 versions
- ►endojournals.org HL Simpson, NC Jackson, F Shojaee-Moradie, … - Journal of Clinical …, 2004 - Endocrine Soc INSULIN RESISTANCE is an important feature of type 1 diabetes. In addition to being insulin
resistant with respect to glucose metabolism (1), patients with type 1 diabetes are also insulin
resistant with respect to lipid and protein metabolism (2, 3). This may in part be mediated ... Cited by 50 - Related articles - BL Direct - All 5 versions
