B Draznin - Diabetes, 2006 - Am Diabetes Assoc Initial attempts to unravel the molecular mechanism of insulin resistance have strongly suggested
that a defect responsible for insulin resistance in the majority of patients lies at the postreceptor
level of insulin signaling. Subsequent studies in insulin-resistant animal models and ... Cited by 51 - Related articles - BL Direct - All 5 versions
B Draznin - DIABETES, 2006 - Am Diabetes Assoc Initial attempts to unravel the molecular mechanism of insulin resistance have strongly suggested
that a defect responsible for insulin resistance in the majority of pa- tients lies at the postreceptor
level of insulin signaling. Subsequent studies in insulin-resistant animal models and ... Related articles
B Draznin - Insulin Resistance: Childhood Precursors and Adult …, 2008 - Springer Even though insulin resistance has emerged as an enormous health care problem, encompassing
the fields of obesity, diabetes, hypertension, and cardiovascular diseases (1 , 2) , its molecular
mechanism remains incompletely understood. Clinically, the term insulin resistance ... Related articles - All 3 versions
R Adochio, JW Leitner, R Hedlund, B Draznin - Endocrinology, 2009 - Endocrine Soc Phosphorylation of insulin receptor substrate-1 (IRS-1) on serine residues has been recognized
as a mechanism responsible for a diminution of insulin action and insulin resistance. Potential
approaches to improve insulin sensitivity may include interference with and/or reduction ... Cited by 1 - Related articles - All 2 versions
- ►endojournals.org [PDF] R Adochio, JW Leitner, R Hedlund, B Draznin - Endocrinology, 2008 - Endocrine Soc Address correspondence and request for reprint to: Boris Draznin, MD, PhD, Director, Adult Diabetes
Program, Professor of Medicine, Division of Endocrinology, Metabolism and Diabetes University
of Colorado Denver, School of Medicine, Anschutz Medical Campus MS 8106 PO Box ... Related articles
MA Cornier, DH Bessesen, I Gurevich, JW Leitner, B … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: We sought to define early molecular alterations associated with nutritionally
induced insulin resistance in humans. Methods: Insulin sensitivity was assessed using a
hyperinsulinaemic–euglycaemic clamp in eight healthy women while on an isocaloric diet ... Cited by 15 - Related articles - BL Direct - All 3 versions
- ►jbc.org LA Barbour, M Rahman… - Journal of Biological Chemistry, 2005 - ASBMB Insulin resistance is a cardinal feature of normal pregnancy and excess growth hormone
(GH) states, but its underlying mechanism remains enigmatic. We previously found a significant
increase in the p85 regulatory subunit of phosphatidylinositol kinase (PI 3-kinase) and ... Cited by 43 - Related articles - BL Direct - All 5 versions
L Qiao, R Zhande, TL Jetton, G Zhou, XJ Sun - Journal of Biological Chemistry, 2002 - ASBMB Insulin resistance is a key pathophysiologic feature of obesity and type 2 diabetes and is associated
with other human diseases, including atherosclerosis, hypertension, hyperlipidemia, and polycystic
ovarian disease. Yet, the specific cellular defects that cause insulin resistance are not ... Cited by 74 - Related articles - BL Direct - All 5 versions
[CITATION] Role of androgen excess on metabolic aberrations and cardiovascular risk in …
