NL Dudek, HE Thomas, L Mariana, RM Sutherland, J … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-cells are the major mediators of β-cell destruction in type 1 diabetes, but the
molecular mechanisms are not definitively established. We have examined the contribution of perforin
and Fas ligand to β-cell ... Cited by 20 - Related articles - BL Direct - All 6 versions
- ►oxfordjournals.org MD McKenzie, NL Dudek, L Mariana, MMW … - International …, 2006 - Jpn Soc Immunol Direct interaction between auto-reactive CTL and specific peptide–MHC class I complexes on
pancreatic beta cells is critical in mediating beta cell destruction in type I diabetes. We used
mice with genetic modifications in ... Cited by 20 - Related articles - All 4 versions
- ►jimmunol.org MMW Chong, Y Chen, R Darwiche, NL … - The Journal of …, 2004 - Am Assoc Immnol In type 1 diabetes, cytokine action on cells potentially contributes to cell destruction by direct
cytotoxicity, inducing Fas expression, and up-regulating class I MHC and chemokine expression to
increase immune recognition. To ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►jimmunol.org J Allison, HE Thomas, T Catterall, TWH Kay, … - The Journal of …, 2005 - Am Assoc Immnol In type 1 diabetes, many effector mechanisms damage the cell, a key one being perforin/granzyme B
production by CD8 + T cells. The death receptor pathway has also been implicated in cell death, and
we have therefore generated NOD ... Cited by 26 - Related articles - All 7 versions
EE Hamilton-Williams, SE Palmer, B … - Proceedings of the …, 2003 - National Acad Sciences Type 1 diabetes occurs as a result of an autoimmune attack on the insulin-producing beta cells.
Although CD8 T cells have been implicated both early and late in this process, the requirement for
direct interaction between these ... Cited by 35 - Related articles - BL Direct - All 8 versions
E Estella, MD McKenzie, T Catterall, VR Sutton, PI Bird, … - Diabetes, 2006 - Am Diabetes Assoc Perforin-deficient NOD mice are protected from diabetes, suggesting that cytotoxic granule contents
of CD8 + T-cells have a significant role in killing β-cells. Despite this, cytotoxic granule
effects on human or mouse ... Cited by 14 - Related articles - BL Direct - All 4 versions
VR Sutton, E Estella, C Li, M Chen, HE Thomas, TW … - Transplantation, 2006 - journals.lww.com Skip Navigation Links Home > January 27, 2006 - Volume 81 - Issue 2 > A Critical Role for Granzyme
B, in Addition to Perforin and... ... Sutton, Vivien R.; Estella, Eugene; Li, Chi; Chen, Melanie;
Thomas, Helen E.; Kay, Thomas W.; ... Cited by 14 - Related articles - BL Direct - All 3 versions
M Flodström-Tullberg, D Yadav, R Hägerkvist, D Tsai, P … - Diabetes, 2003 - Am Diabetes Assoc Although lymphocyte infiltration and islet destruction are hallmarks of diabetes, the mechanisms of
β-cell destruction are not fully understood. One issue that remains unresolved is whether cytokines
play a direct role in β-cell ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Kim, HS Kim, KW Chung, SH Oh, JW Yun, SH Im, MK … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—STAT1 −/− islet cells were resistant to death by interferon (IFN)-γ/tumor necrosis
factor (TNF)-α or IFN-γ/interleukin (IL)-1β combination. Cytochrome c translocation by
IFN-γ/TNF-α was abrogated in ... Cited by 8 - Related articles - BL Direct - All 6 versions
PD Campbell, E Estella, NL Dudek, G Jhala, HE … - Human Immunology, 2008 - Elsevier Cytotoxic T lymphocytes (CTL) are believed to play an essential role in β-cell destruction leading
to development of type 1 diabetes and allogeneic islet graft failure. We aimed to identify the
mechanisms used by CTL to kill ... Cited by 2 - Related articles - All 2 versions
