- ►diabetesjournals.org N Zhang, D Su, S Qu, T Tse, R Bottino, AN … - Diabetes, 2006 - Am Diabetes Assoc Successful islet transplantation depends on the infusion of sufficiently large
quantities of islets, but only a fraction of transplanted islets can survive and
become engrafted, and yet the underlying mechanism remains unclear. In this ... Cited by 41 - Related articles - BL Direct - All 7 versions
CT Bussiere, JRT Lakey, AMJ Shapiro, GS … - Diabetologia, 2006 - Springer Abstract Aims/hypothesis The Edmonton Protocol for islet trans- plantation has
provided hope for type 1 diabetic patients. However, this protocol requires
lifelong immunosuppres- sion, specifically sirolimus, a cellular ... Cited by 28 - Related articles - BL Direct - All 4 versions
- ►daegu.ac.kr [PDF] S Marcelli-Tourvieille, T Hubert, E Moerman … - Transplantation, 2007 - journals.lww.com Skip Navigation Links Home > March 15, 2007 - Volume 83 - Issue 5 > In Vivo and
In Vitro Effect of Sirolimus on Insulin Secretio... ... 1 Department of
Endocrinology and Metabolism and Endocrine Surgery, INSERM Unit-M859, ... Cited by 10 - Related articles - BL Direct - All 6 versions
V Cantaluppi, L Biancone, GM Romanazzi, F … - American Journal of Transplantation, 2006 - interscience.wiley.com Donor intra-islet endothelial cells contribute to neovascularization after
transplantation. Several factors may interfere with this process and ultimately
influence islet engraftment. Rapamycin, a central immunosuppressant in ... Cited by 26 - Related articles - BL Direct - All 5 versions
E Bell, X Cao, JA Moibi, SR Greene, R Young, … - Diabetes, 2003 - Am Diabetes Assoc Rapamycin (sirolimus) is a macrolide fungicide with immunosuppressant properties
that is used in human islet transplantation. Little is known about the effects
of rapamycin on MIN-6 cells and islets. Rapamycin had a dose-dependent, ... Cited by 73 - Related articles - BL Direct - All 4 versions
NM Desai, JA Goss, S Deng, BA Wolf, E … - Transplantation, 2003 - journals.lww.com Desai, Niraj M.; Goss, John A.; Deng, Shaoping; Wolf, Bryan A.; Markmann,
Eileen; Palanjian, Maral; Shock, Angela P.; Feliciano, Sue; Brunicardi, F.
Charles; Barker, Clyde F.; Naji, Ali; Markmann, James F. Cited by 48 - Related articles - BL Direct - All 3 versions
AM Shapiro, HL Gallant, EG Hao, JRT Lakey, … - Therapeutic drug monitoring, 2005 - journals.lww.com Abstract: Outcomes in clinical islet transplantation improved substantially with
the introduction of combined sirolimus and tacrolimus immunosuppression.
However, multiple islet preparations are often required to achieve insulin ... Cited by 41 - Related articles - All 4 versions
- ►duke.edu [PDF] R Olsson, PO Carlsson - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier The pancreatic islets are one of the most vascularized organs of the body. This
likely reflects the requirements of the organ for a rich supply of nutrients and
oxygen to the tissue, as well as the need for rapid disposal of metabolites ... Cited by 18 - Related articles - All 9 versions
- ►diabetesjournals.org M Fraenkel, M Ketzinel-Gilad, Y Ariav, O … - Diabetes, 2008 - Am Diabetes Assoc RESULTS—Unexpectedly, rapamycin worsened hyperglycemia in diabetic P. obesus
without affecting glycemia in normoglycemic controls. There was a 10-fold
increase of serum insulin in diabetic P. obesus compared with controls; ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►asnjournals.org S Di Paolo, A Teutonico, D Leogrande, C … - Journal of the American Society of Nephrology, 2006 - Am Soc Nephrol Overactivation of the mammalian target of rapamycin (mTOR) branch downstream of
the phosphatidylinositol 3-kinase–AKT pathway critically modulates insulin and
growth factor signaling by insulin receptor substrates (IRS). On the basis ... Cited by 23 - Related articles - All 6 versions
