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Scholar Results 1 - 10 of about 101 related to Maedler: Aging correlates with decreased {beta}-cell proliferative capacity and enhanced.... (0.09 sec) 

Aging correlates with decreased {beta}-cell proliferative capacity and enhanced sensitivity …

- diabetesjournals.org
K Maedler, DM Schumann, F Schulthess, J … - Diabetes, 2006 - Am Diabetes Assoc
Type 2 diabetes is characterized by a deficit in β-cell mass, and its incidence
increases with age. Here, we analyzed β-cell turnover in islets from 2- to 3-
compared with 7- to 8-month-old rats and in human islets from 53 organ ...
Cited by 28 - Related articles - BL Direct - All 4 versions

Aging Correlates With Decreased-Cell Proliferative Capacity and Enhanced Sensitivity to …


K Maedler, DM Schumann, F Schulthess, J … - 糖尿病学杂志, 2006 - journal.shouxi.net
Type 2 diabetes is characterized by a deficit in -cell mass, and its incidence
increases with age. Here, we analyzed -cell turnover in islets from 2- to 3-
compared with 7- to 8-month-old rats and in human islets from 53 organ ...
Related articles - Cached

A Potential Role for Fas and Pancreatic Duodenal Homeobox-1


K Maedler, DM Schumann, F Schulthess, J … - DIABETES, 2006 - Am Diabetes Assoc
Type 2 diabetes is characterized by a deficit in -cell mass, and its incidence
increases with age. Here, we analyzed -cell turnover in islets from 2- to 3-
compared with 7- to 8-month-old rats and in human islets from 53 organ ...
Related articles

Low Concentration of Interleukin-1β Induces FLICE-Inhibitory Protein–Mediated β-Cell …

- diabetesjournals.org
K Maedler, DM Schumann, N Sauter, H … - Diabetes, 2006 - Am Diabetes Assoc
High glucose concentrations have a dual effect on β-cell turnover, inducing
proliferation in the short-term and apoptosis in the long-term. Hyperglycemia
leads to β-cell production of interleuking (IL)-1β in human pancreatic ...
Cited by 30 - Related articles - BL Direct - All 4 versions

Effect of donor age on function of isolated human islets

- diabetesjournals.org
SH Ihm, I Matsumoto, T Sawada, M Nakano, … - Diabetes, 2006 - Am Diabetes Assoc
This study intended to evaluate the impact of donor age on the function of
isolated islets. Analysis of human islets from cadaveric donors (age 16–70
years) was performed using glucose-stimulated insulin release (GSIR) (n = ...
Cited by 22 - Related articles - BL Direct - All 6 versions

Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent- …


JJ Meier, JC Lin, AE Butler, R Galasso, DS … - Diabetologia, 2006 - Springer
Abstract Aims/hypothesis We investigated whether there was evi- dence of
attempted beta cell regeneration in the pancreas obtained from a patient with
recent-onset type 1 diabetes, and if so by what mechanism this occurred. ...
Cited by 53 - Related articles - BL Direct - All 4 versions

Impaired islet turnover in human donor pancreata with aging


C Reers, S Erbel, I Esposito, B Schmied, MW … - European Journal of Endocrinology, 2009 - EFES
Materials and methods: Human pancreatic tissue from n=20 non-diabetic organ
donors with a mean age of 50.2±3.5 years (range 7–66 years) and mean body
mass index of 25.7±0.9 kg/m 2 (17.2–33.1 kg/m 2 ) was morphometrically ...
Cited by 2 - Related articles - All 7 versions

[CITATION] kajimoto, Y., Yasuda, T., Matsuoka, T


Y Fujitani - A., Kaneto, H., Umayahara, Y., Fujita, N., Watada, H., …, 1999
Cited by 2 - Related articles

Stimulation of pancreatic {beta}-cell replication by incretins involves transcriptional …

- endocrinology-journals.org
BN Friedrichsen, N Neubauer, YC Lee, VK … - Journal of Endocrinology, 2006 - Soc Endocrinology
The incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic peptide (GIP), have been suggested to act as ß-cell growth
factors and may therefore be of critical importance for the maintenance of ...
Cited by 34 - Related articles - BL Direct - All 4 versions

The effect of donor factors on human islet yield and their in vivo function.


OM Sabek, P Cowan, DW Fraga, AO Gaber - Progress in transplantation (Aliso Viejo, Calif.), 2006 - ncbi.nlm.nih.gov
BACKGROUND: A major problem in the islet field is the high selectivity exercised
in accepting cadaveric pancreas for islet isolation. This practice is based on
experience that indicates that islet yield and posttransplant function are ...
Cited by 3 - Related articles - BL Direct


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