W Wente, AM Efanov, M Brenner, A … - Diabetes, 2006 - Am Diabetes Assoc Fibroblast growth factor-21 (FGF-21) is a recently discovered metabolic
regulator. Here, we investigated the effects of FGF-21 in the pancreatic
β-cell. In rat islets and INS-1E cells, FGF-21 activated extracellular ... Cited by 56 - Related articles - BL Direct - All 4 versions
- ►endojournals.org A Kharitonenkov, VJ Wroblewski, A Koester, … - Endocrinology, 2007 - Endocrine Soc Fibroblast growth factor (FGF)-21 has been recently characterized as a potent
metabolic regulator. Systemic administration of FGF-21 reduced plasma glucose
and triglycerides to near normal levels in genetically compromised diabetic ... Cited by 59 - Related articles - BL Direct - All 4 versions
JS Moyers, TL Shiyanova, F Mehrbod, JD … - Journal of cellular physiology, 2007 - interscience.wiley.com Fibroblast growth factor (FGF)-21 is a novel regulator of insulin-independent
glucose transport in 3T3-L1 adipocytes and has glucose and triglyceride lowering
effects in rodent models of diabetes. The precise mechanisms whereby FGF-21 ... Cited by 35 - Related articles - BL Direct - All 3 versions
T Lundåsen, MC Hunt, LM Nilsson, S Sanyal, … - Biochemical and biophysical research communications, 2007 - Elsevier The metabolic regulator fibroblast growth factor 21 (FGF21) has antidiabetic
properties in animal models of diabetes and obesity. Using quantitative RT-PCR,
we here show that the hepatic gene expression of FGF21 is regulated by the ... Cited by 35 - Related articles - All 4 versions
X Zhang, DCY Yeung, M Karpisek, D Stejskal … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Serum FGF21 levels in overweight/obese subjects were significantly
higher than in lean individuals. Serum FGF21 correlated positively with
adiposity, fasting insulin, and triglycerides but negatively with HDL ... Cited by 25 - Related articles - BL Direct - All 4 versions
- ►nih.gov A Kharitonenkov, TL Shiyanova, A Koester, … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Diabetes mellitus is a major health concern, affecting more than 5% of the
population. Here we describe a potential novel therapeutic agent for this
disease, FGF-21, which was discovered to be a potent regulator of glucose ... Cited by 136 - Related articles - All 12 versions
- ►upenn.edu [PDF] MK Badman, P Pissios, AR Kennedy, G Koukos, … - Cell metabolism, 2007 - Elsevier Mice fed a high-fat, low-carbohydrate ketogenic diet (KD) exhibit marked changes
in hepatic metabolism and energy homeostasis. Here, we identify liver-derived
fibroblast growth factor 21 (FGF21) as an endocrine regulator of the ... Cited by 81 - Related articles - All 7 versions
A Kharitonenkov, JD Dunbar, HA Bina, S … - Journal of cellular physiology, 2008 - interscience.wiley.com Fibroblast growth factor-21 (FGF-21) is a metabolic regulator that can influence
glucose and lipid control in diabetic rodents and primates. We demonstrate that
Klotho is an integral part of an activated FGF-21- Klotho-FGF receptor ... Cited by 26 - Related articles - BL Direct - All 2 versions
- ►cell.com T Inagaki, P Dutchak, G Zhao, X Ding, L … - Cell metabolism, 2007 - Elsevier Peroxisome proliferator-activated receptor α (PPARα) regulates the utilization
of fat as an energy source during starvation and is the molecular target for the
fibrate dyslipidemia drugs. Here, we identify the endocrine hormone ... Cited by 96 - Related articles - All 10 versions
- ►sciencesignaling.org Y Ogawa, H Kurosu, M Yamamoto, A Nandi, … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences Fibroblast growth factor 21 (FGF21) is a liver-derived endocrine factor that
stimulates glucose uptake in adipocytes. Here, we show that FGF21 activity
depends on βKlotho, a single-pass transmembrane protein whose expression ... Cited by 54 - Related articles - BL Direct - All 13 versions
