G Proctor, T Jiang, M Iwahashi, Z Wang, J Li, M Levi - Diabetes, 2006 - Am Diabetes Assoc In Akita and OVE26 mice, two genetic models of type 1 diabetes, diabetic nephropathy is characterized
by mesangial expansion and loss of podocytes, resulting in glomerulosclerosis and
proteinuria, and is associated with increased expression of profibrotic growth factors, ... Cited by 29 - Related articles - BL Direct - All 5 versions
- ►jbc.org L Sun, N Halaihel, W Zhang, T Rogers, M Levi - Journal of Biological Chemistry, 2002 - ASBMB Diabetic renal disease is associated with lipid deposits in the kidney. The purpose of our study
was to determine whether there is altered regulation of the sterol regulatory element-binding
proteins (SREBPs) in the diabetic kidney and whether SREBPs mediate the abnormal ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►jbc.org T Jiang, Z Wang, G Proctor, S Moskowitz, SE … - Journal of Biological …, 2005 - ASBMB Obesity and metabolic syndrome are associated with glomerulosclerosis and proteinuria, but
the mechanisms are not known. The purpose of this study was to determine if there is altered
renal lipid metabolism and increased expression of sterol regulatory element-binding ... Cited by 58 - Related articles - BL Direct - All 5 versions
T Jiang, SE Liebman, MS Lucia, J Li, M Levi - Kidney international, 2005 - nature.com There are well-known changes in age-related renal function and structure, including glomerulosclerosis
and decline in glomerular filtration rate (GFR). The purpose of this study was to identify a potential
role for lipids in mediating age-related renal disease. ... Mice of five different age groups ... Cited by 31 - Related articles - BL Direct - All 5 versions
N Ishigaki, T Yamamoto, Y Shimizu, K Kobayashi, S … - … and Biophysical Research …, 2007 - Elsevier The role of glomerular SREBP-1c in diabetic nephropathy was investigated. PEPCK-promoter
transgenic mice overexpressing nuclear SREBP-1c exhibited enhancement of proteinuria with
mesangial proliferation and matrix accumulation, mimicking diabetic nephropathy, ... Cited by 6 - Related articles - All 3 versions
S Zheng, WT Noonan, NS Metreveli, S Coventry, PM … - Diabetes, 2004 - Am Diabetes Assoc OVE26 mice are a transgenic model of severe early-onset type 1 diabetes. These mice develop
diabetes within the first weeks of life and can survive well over a year with no insulin
treatment, and they maintain near normal body weight. To determine whether OVE26 ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org Z Wang, T Jiang, J Li, G Proctor, JL McManaman, S … - Diabetes, 2005 - Am Diabetes Assoc Diabetic kidney disease has been associated with the presence of lipid deposits, but the mechanisms
for the lipid accumulation have not been fully determined. In the present study, we found that
db/db mice on the FVB genetic background with loss-of-function mutation of the leptin ... Cited by 45 - Related articles - BL Direct - All 5 versions
X Ruan, J Moorhead, R Fernando, D … - Biochemical Society …, 2004 - bst.portlandpress.com Inflammation and dyslipidaemia both play important roles in the development of glomerular atherosclerosis
in renal diseases. We have demonstrated that inflammatory mediators induced Scr (scavenger
receptor) expression and the formation of foam cells, and that AP-1 (activator protein ... Cited by 26 - Related articles - Cached - BL Direct - All 9 versions
- ►asnjournals.org T Jiang, SE Liebman, MS Lucia, CL Phillips, … - Journal of the American …, 2005 - Am Soc Nephrol Sterol regulatory element binding proteins (SREBP) are major regulators of fatty acid and cholesterol
synthesis. This study found that age-related renal matrix deposition and proteinuria were associated
with increased renal expression of SREBP-1 and SREBP-2 and increased renal ... Cited by 15 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org T Jiang, XX Wang, P Scherzer, P Wilson, J Tallman, H … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Recent studies indicate an important role for nuclear receptors in regulating lipid
and carbohydrate metabolism, fibrosis, and inflammation. Farnesoid X receptor (FXR) is a member
of the nuclear hormone receptor superfamily. FXR is highly expressed in the liver, ... Cited by 18 - Related articles - BL Direct - All 3 versions
