F Samad, KD Hester, G Yang, YA Hannun, J … - Diabetes, 2006 - Am Diabetes Assoc The adipose tissue has become a central focus in the pathogenesis of
obesity-mediated cardiovascular and metabolic disease. Here we demonstrate that
adipose sphingolipid metabolism is altered in genetically obese (ob/ob) ... Cited by 23 - Related articles - BL Direct - All 5 versions
L Pickersgill, GJ Litherland, AS Greenberg, … - Journal of Biological Chemistry, 2007 - ASBMB Elevated non-esterified fatty acids, triglyceride, diacylglycerol, and ceramide
have all been associated with insulin resistance in muscle. We set out to
investigate the role of intramyocellular lipid metabolites in the induction ... Cited by 23 - Related articles - All 11 versions
C Shah, G Yang, I Lee, J Bielawski, YA … - Journal of Biological Chemistry, 2008 - ASBMB Obesity increases the risk for metabolic and cardiovascular disease, and adipose
tissue plays a central role in this process. Ceramide, the key intermediate of
sphingolipid metabolism, also contributes to obesity-related disorders. We ... Cited by 9 - Related articles - All 4 versions
F Samad - Future Lipidol., 2007 - Future Medicine Insulin resistance, Type 2 diabetes and accelerated atherosclerosis are common
health complications associated with obesity, and increasing evidence suggest
that a complex proinflammatory state together with increased lipid ... Cited by 2 - Related articles - BL Direct - All 3 versions
Z Li, MJ Basterr, TK Hailemariam, MR Hojjati, … - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier Sphingomyelin (SM) plays a very important role in cell membrane formation and
plasma lipoprotein metabolism. All these functions may have an impact on
atherosclerotic development. To investigate the relationship between SM ... Cited by 14 - Related articles - All 3 versions
A Planavila, M Alegret, RM Sánchez, R … - Biochemical pharmacology, 2005 - Elsevier Although it is generally believed that thiazolidinediones ameliorate insulin
resistance by lowering circulating free fatty acids, direct effects of these
drugs in skeletal muscle may also contribute to their antidiabetic action. ... Cited by 14 - Related articles - All 3 versions
- ►endojournals.org WL Holland, SA Summers - Endocrine Reviews, 2008 - Endocrine Soc Obesity and dyslipidemia are risk factors for metabolic disorders including
diabetes and cardiovascular disease. Sphingolipids such as ceramide and
glucosylceramides, while being a relatively minor component of the lipid ... Cited by 29 - Related articles - All 7 versions
M Zendzian-Piotrowska, M Baranowski, P … - J Physiol Pharmacol, 2006 - jpp.krakow.pl Ceramide is involved in the pathogenesis of insulin resistance in skeletal
muscles of humans and rodents. However, there are conflicting reports in the
literature on the effect of thiazolidinediones (a new class of insulin ... Cited by 7 - Related articles - Cached - All 7 versions
M Skovbro, M Baranowski, C Skov-Jensen, A … - Diabetologia, 2008 - Springer Abstract Aims/hypothesis In skeletal muscle, ceramides may be involved in the
pathogenesis of insulin resistance through an attenuation of insulin signalling.
This study investigated total skeletal muscle ceramide fatty acid content ... Cited by 9 - Related articles - BL Direct - All 2 versions
- ►endojournals.org DJ Jun, JH Lee, BH Choi, TK Koh, DC Ha, MW … - Endocrinology, 2006 - Endocrine Soc Sphingosine-1-phosphate (S1P) is a pluripotent lipid mediator that transmits
signals through a family of G protein-coupled receptors to control diverse
biological processes. Here, we investigated the effects of S1P on the ... Cited by 9 - Related articles - BL Direct - All 6 versions
