V Seyfert-Margolis, TD Gisler, AL Asare, RS … - Diabetes, 2006 - Am Diabetes Assoc Type 1 diabetes is a chronic autoimmune disease mediated by autoreactive
T-cells. Several experimental therapies targeting T-cells are in clinical
trials. To understand how these therapies affect T-cell responses in vivo, ... Cited by 20 - Related articles - BL Direct - All 8 versions
BM Brooks-Worrell, GA Starkebaum, C … - The Journal of Immunology, 1996 - Am Assoc Immnol Peripheral Blood Mononuclear Cells of Insulin-Dependent ... Diabetic Patients
Respond to Multiple Islet Cell Proteins' ... Barbara M. Brooks-Worrell,2*t
Gordon A. Starkebaum,*' Carla Greenbaum,*t and Jerry P. Palme& Cited by 34 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org B Brooks-Worrell, VH Gersuk, C Greenbaum, … - The Journal of Immunology, 2001 - Am Assoc Immnol Intra- and intermolecular spreading of T cell responses to autoantigens has been
implicated in the pathogenesis of autoimmune diseases. Therefore, we questioned
whether T cell responses from subjects identified as at-risk (positive for ... Cited by 31 - Related articles - BL Direct - All 3 versions
- ►jimmunol.org P Monti, M Scirpoli, A Rigamonti, A Mayr, A … - The Journal of Immunology, 2007 - Am Assoc Immnol Identifying cell autoantigen-reactive T cells that are involved in the
pathogenesis of type 1 diabetes has been troublesome for many laboratories.
Disease-relevant autoreactive T cells should be in vivo Ag experienced. The ... Cited by 17 - Related articles - All 4 versions
P Van Endert, Y Hassainya, V Lindo, J Bach, … - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2006 - interscience.wiley.com Abstract: Type 1 diabetes mellitus (T1DM) results from the destruction of β
cells by autoantigen-specific T cells. In the non-obese diabetic (NOD) mouse
model, CD8 + T cells play an essential role in both the initial triggering ... Cited by 8 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org J Yang, NA Danke, DA Berger, S … - The Journal of Immunology, 2006 - Am Assoc Immnol Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP) is
recognized as a major autoantigen for autoimmune type 1 diabetes (T1D) in the
NOD mouse model. This study was undertaken to examine CD4 + T cell ... Cited by 25 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org NE Standifer, Q Ouyang, C Panagiotopoulos, … - Diabetes, 2006 - Am Diabetes Assoc Cytotoxic T-lymphocytes (CTLs) are considered to be essential for β-cell
destruction in type 1 diabetes. However, few islet-associated peptides have been
demonstrated to activate autoreactive CTLs from type 1 diabetic subjects. ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►jimmunol.org HM Dosch, RK Cheung, W Karges, M … - The Journal of Immunology, 1999 - Am Assoc Immnol An anergic phenotype has been observed in nonobese diabetic (NOD) mice and some
autoreactive T cells from patients with type I diabetes. To better understand
this phenomenon, we measured T cell proliferative responses to 10 diabetes- ... Cited by 41 - Related articles - BL Direct - All 2 versions
- ►alaskaclinicaltrials.org [PDF] V Öling, J Marttila, J Ilonen, WW Kwok, G … - Journal of Autoimmunity, 2005 - Elsevier In type 1 diabetes the major loss of insulin producing beta-cells is caused by
autoreactive T-cells specific for antigens expressed by the pancreatic islets.
In this study we have analyzed the prevalence of glutamate decarboxylase 65 ... Cited by 23 - Related articles - All 8 versions
- ►rupress.org SI Mannering, LC Harrison, NA Williamson, … - Journal of Experimental Medicine, 2005 - jem.rupress.org The autoimmune process that destroys the insulin-producing pancreatic ß cells
in type 1 diabetes (T1D) is targeted at insulin and its precursor, proinsulin. T
cells that recognize the proximal A-chain of human insulin were identified ... Cited by 25 - Related articles - BL Direct - All 10 versions
