- ►diabetesjournals.org BE Levin, L Kang, NM Sanders, AA Dunn-Meynell - Diabetes, 2006 - Am Diabetes Assoc Glucosensing is a property of specialized neurons in the brain that regulate their membrane
potential and firing rate as a function of ambient glucose levels. These neurons have several
similarities to β- and α-cells in the pancreas, which are also responsive to ambient ... Cited by 17 - Related articles - BL Direct - All 4 versions
NM Sanders, GJ Taborsky, CW Wilkinson, W Daumen, … - Diabetes, 2007 - Am Diabetes Assoc Recurrent hypoglycemia impairs hormonal counterregulatory responses (CRRs) to further bouts
of hypoglycemia. The hypothalamus and hindbrain are both critical for sensing hypoglycemia
and triggering CRRs. Hypothalamic glucose sensing sites are implicated in the ... Cited by 3 - Related articles - BL Direct - All 5 versions
- ►nih.gov Q Tong, CP Ye, RJ McCrimmon, H Dhillon, B Choi, MD … - Cell metabolism, 2007 - Elsevier The importance of neuropeptides in the hypothalamus has been experimentally established.
Due to difficulties in assessing function in vivo, the roles of the fast-acting neurotransmitters glutamate
and GABA are largely unknown. Synaptic vesicular transporters (VGLUTs for glutamate ... Cited by 22 - Related articles - All 6 versions
- ►shouxi.net O Chan, W Zhu, Y Ding, RJ McCrimmon, RS Sherwin - Diabetes, 2006 - Am Diabetes Assoc Hypoglycemia provokes a multifaceted counterregulatory response involving the sympathoadrenal
system, stimulation of glucagon secretion, and the hypothalamo-pituitary-adrenal axis that is
commonly impaired in diabetes. We examined whether modulation of inhibitory input from ... Cited by 11 - Related articles - BL Direct - All 5 versions
CM Donovan, AL Hevener, RN Bergman - Current Opinion in …, 1998 - journals.lww.com Hypoglycemic detection, long attributed exclusively to the brain, is now known to occur in the
portal vein. Using the local irrigation technique, it has been repeatedly shown that hypoglycemia
in the portohepatic region is essential to engendering the full catecholamine response. ... Cited by 2 - Related articles - BL Direct
- ►diabetesjournals.org RJ McCrimmon, ML Evans, X Fan, EC McNay, O Chan, … - Diabetes, 2005 - Am Diabetes Assoc The mechanism(s) by which glucosensing neurons detect fluctuations in glucose remains largely
unknown. In the pancreatic β-cell, ATP-sensitive K + channels (K ATP channels) play a key role
in glucosensing by providing a link between neuronal metabolism and membrane ... Cited by 24 - Related articles - BL Direct - All 6 versions
S Fujita, CM Donovan - Diabetes, 2005 - Am Diabetes Assoc Afferent innervation of the portal vein has been shown to be critical in hypoglycemic
detection, but the neural pathway by which these afferents ascend remains unknown. To ascertain
the role of vagal afferents versus spinal afferents in hypoglycemic detection, the ... Cited by 14 - Related articles - BL Direct - All 5 versions
- ►physiology.org SF Andrew, TT Dinh, S Ritter - American Journal of Physiology- …, 2007 - Am Physiological Soc Glucose is required for brain energy metabolism. Decerebration, aqueduct occlusion, and cannula
mapping studies have established that glucose-sensing cells capable of eliciting feeding and
adrenal medullary responses to glucoprivation are localized in the hindbrain. ... Cited by 5 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org S Migrenne, C Cruciani-Guglielmacci, L Kang, R Wang, … - Diabetes, 2006 - Am Diabetes Assoc It is now clearly demonstrated that fatty acids (FAs) may modulate neural control of energy homeostasis
and specifically affect both insulin secretion and action. Indeed, pancreatic β-cells receive rich
neural innervation and FAs induce important changes in autonomic nervous activity. We ... Cited by 5 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org RJ McCrimmon, X Fan, H Cheng, E McNay, O Chan, M … - Diabetes, 2006 - Am Diabetes Assoc Defective counterregulatory responses (CRRs) to hypoglycemia are associated with a marked
increase in the risk of severe hypoglycemia. The mechanisms leading to the development of
defective CRRs remain largely unknown, although they are associated with antecedent ... Cited by 28 - Related articles - BL Direct - All 5 versions
