- ►diabetesjournals.org CJ Nolan, MSR Madiraju, V Delghingaro-Augusto, ML … - Diabetes, 2006 - Am Diabetes Assoc Fatty acids (FAs) and other lipid molecules are important for many cellular functions, including
vesicle exocytosis. For the pancreatic β-cell, while the presence of some FAs is essential for
glucose-stimulated insulin ... Cited by 55 - Related articles - BL Direct - All 5 versions
CJ Nolan, JL Leahy, V Delghingaro-Augusto, J Moibi, K … - Diabetologia, 2006 - Springer Page 1. ARTICLE Beta cell compensation for insulin resistance in Zucker fatty rats: increased lipolysis
and fatty acid signalling CJ Nolan & JL Leahy & V. Delghingaro-Augusto & J. Moibi & K. Soni & M.-L.
Peyot & M. Fortier & C. Guay & J. Lamontagne & A. Barbeau & E. Przybytkowski & ... Cited by 44 - Related articles - BL Direct - All 3 versions
- ►diabetesjournals.org ML Peyot, CJ Nolan, K Soni, E Joly, R Lussier, BE … - Diabetes, 2004 - Am Diabetes Assoc We previously reported decreased glucose-stimulated insulin secretion (GSIS) in hormone-sensitive
lipase-null mice (HSL −/− ), both in vivo and in vitro. The focus of the current study was to
gain further insight into the ... Cited by 34 - Related articles - BL Direct - All 6 versions
- ►usu.edu [PDF] A Salehi, E Flodgren, NE Nilsson, J Jimenez- … - Cell and tissue research, 2005 - Springer Abstract Free fatty acids (FFA) have generally been proposed to regulate pancreatic insulin release
by an intracellular mechanism involving inhibition of CPT-1. The recently de-orphanized G-protein
coupled receptor, FFA 1 R/GPR40, ... Cited by 48 - Related articles - BL Direct - All 5 versions
- ►endojournals.org M Prentki, SR Madiraju - Endocrine reviews, 2008 - Endocrine Soc GL/FFA cycle is referred to as a "futile" cycle because it involves continuous formation and
hydrolysis of GL with the release of heat, at the expense of ATP. However, we present evidence
underscoring the "vital" cellular ... Cited by 14 - Related articles - All 5 versions
H Mulder, S Yang, MS Winzell, C Holm, B Ahrén - Diabetes, 2004 - Am Diabetes Assoc Lipids may serve as coupling factors in K ATP -independent glucose sensing in β-cells. We have
previously demonstrated that β-cells harbor lipase activities, one of which is the
hormone-sensitive lipase. Whether ... Cited by 40 - Related articles - BL Direct - All 5 versions
- ►cell.com CJ Nolan, M Prentki - Trends in Endocrinology & Metabolism, 2008 - Elsevier The pancreatic β-cell senses blood nutrient levels and is modulated by neurohormonal signals so
that it secretes insulin according to the need of the organism. Nutrient sensing involves marked
metabolic activation, resulting in ... Cited by 7 - Related articles - All 8 versions
DK Covington, CA Briscoe, AJ Brown, CK … - Biochemical Society …, 2006 - biochemsoctrans.cn Abstract Recent deorphanization efforts have paired the G-protein-coupled receptors GPR40, GPR41 and
GPR43 with fatty acids as endogenous ligands. While carboxylic acids have been historically known to
serve as fuel sources and ... Cited by 35 - Related articles - View as HTML - BL Direct - All 5 versions
MG Latour, T Alquier, E Oseid, C Tremblay, TL Jetton, J … - Diabetes, 2007 - Am Diabetes Assoc Long-chain fatty acids amplify insulin secretion from the pancreatic β-cell. The
G-protein–coupled receptor GPR40 is specifically expressed in β-cells and is activated by fatty
acids; however, its role in acute ... Cited by 47 - Related articles - BL Direct - All 6 versions
H Shapiro, S Shachar, I Sekler, M Hershfinkel, MD … - … and Biophysical Research …, 2005 - Elsevier GPR40 is a G protein-coupled receptor expressed preferentially in β cells, that has been implicated
in mediating free fatty acid-stimulated insulin release. GPR40 RNAi impaired the ability of palmitic
acid (PA) to increase both insulin ... Cited by 50 - Related articles - All 5 versions
