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Glucagon-like peptide 1 secretion by the L-cell


GE Lim, PL Brubaker - Diabetes, 2006 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) is a gut-derived peptide secreted from
intestinal L-cells after a meal. GLP-1 has numerous physiological actions,
including potentiation of glucose-stimulated insulin secretion, enhancement ...
Cited by 18 - Related articles - BL Direct - All 4 versions

[PDF] The View From Within


GE Lim, PL Brubaker - Diabetes, 2006 - Am Diabetes Assoc
Glucagon-like peptide 1 (GLP-1) is a gut-derived peptide secreted from
intestinal L-cells after a meal. GLP-1 has numerous physiological actions,
including potentiation of glucose-stimulated insulin secretion, enhancement ...
Related articles - All 2 versions

A role for intestinal endocrine cell-expressed g protein-coupled receptor 119 in glycemic …

- endojournals.org
ZL Chu, C Carroll, J Alfonso, V Gutierrez, … - Endocrinology, 2008 - Endocrine Soc
We recently showed that activation of G protein-coupled receptor 119 (GPR119)
(also termed glucose dependent insulinotropic receptor) improves glucose
homeostasis via direct cAMP-mediated enhancement of glucose-dependent ...
Cited by 23 - Related articles - BL Direct - All 2 versions

Somatostatin-28 regulates GLP-1 secretion via somatostatin receptor subtype 5 in rat …

- physiology.org
C Chisholm, GR Greenberg - American Journal of Physiology- Endocrinology And …, 2002 - Am Physiological Soc
Five somatostatin receptors (SSTRs) bind somatostatin-14 (S-14) and
somatostatin-28 (S-28), but SSTR5 has the highest affinity for S-28. To
determine whether S-28 acting through SSTR5 mediates inhibition of ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Glucose sensing in L cells: a primary cell study

- nih.gov
F Reimann, AM Habib, G Tolhurst, HE Parker, … - Cell Metabolism, 2008 - Elsevier
Glucagon-like peptide-1 (GLP-1) is an enteric hormone that stimulates insulin
secretion and improves glycaemia in type 2 diabetes. Although GLP-1-based
treatments are clinically available, alternative strategies to increase ...
Cited by 12 - Related articles - All 11 versions

Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal …

- endojournals.org
F Yi, J Sun, GE Lim, IG Fantus, PL Brubaker, T … - Endocrinology, 2008 - Endocrine Soc
The proglucagon gene (glu) encodes the incretin hormone glucagon-like peptide-1
(GLP-1), produced in the intestinal endocrine L cells. We found previously that
the bipartite transcription factor β-catenin/T cell factor (cat/TCF), the ...
Cited by 13 - Related articles - BL Direct - All 3 versions

Protein kinase C {zeta} is required for oleic acid-induced secretion of glucagon-like peptide-1 …

- endojournals.org
R Iakoubov, A Izzo, A Yeung, CI Whiteside, … - Endocrinology, 2007 - Endocrine Soc
Long-chain, monounsaturated fatty acids (FAs) stimulate secretion of the
incretin hormone, glucagon-like peptide-1 (GLP-1) from the intestinal L cell.
Because the atypical protein kinase C (PKC), PKC , is involved in FA ...
Cited by 11 - Related articles - BL Direct - All 4 versions

A role for {beta}-cell-expressed G protein-coupled receptor 119 in glycemic control by …

- endojournals.org
ZL Chu, RM Jones, H He, C Carroll, V … - Endocrinology, 2007 - Endocrine Soc
Pancreatic ß-cell dysfunction is a hallmark event in the pathogenesis of type 2
diabetes. Injectable peptide agonists of the glucagon-like peptide 1 (GLP-1)
receptor have shown significant promise as antidiabetic agents by virtue of ...
Cited by 33 - Related articles - BL Direct - All 5 versions

Mechanisms of Action of GLP-1 in the Pancreas


ME Doyle, JM Egan - Pharmacology & therapeutics, 2007 - pubmedcentral.nih.gov
Cited by 3 - Related articles

Insulin regulates glucagon-like peptide-1 secretion from the enteroendocrine L cell


GE Lim, GJ Huang, N Flora, D LeRoith, CJ … - Endocrinology, 2009 - Endocrine Soc
Insulin resistance and type 2 diabetes mellitus are associated with impaired
postprandial secretion of glucagon-like peptide-1 (GLP-1), a potent
insulinotropic hormone. The direct effects of insulin and insulin ...
Cited by 5 - Related articles - All 3 versions


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