- ►diabetesjournals.org JH Oak, H Cai - Diabetes, 2007 - Am Diabetes Assoc Angiotensin II (Ang II) levels are increased in patients with diabetes, but
mechanisms underlying its contribution to diabetic vascular diseases are
incompletely understood. We recently reported that in aortic endothelial ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►ahajournals.org YH Du, YY Guan, NJ Alp, KM Channon, AF … - Circulation, 2008 - Am Heart Assoc Background— Tetrahydrobiopterin (BH4) is an essential cofactor of endothelial
nitric oxide synthase (eNOS). When BH4 levels are decreased, eNOS becomes
uncoupled to produce superoxide anion (O 2 – ) instead of NO, which ... Cited by 18 - Related articles - All 5 versions
- ►ahajournals.org W Hodroj, L Legedz, N Foudi, C Cerutti, MC … - Arteriosclerosis, thrombosis, and vascular biology, 2007 - Am Heart Assoc Methods and Results— mRNA and protein levels of angiotensinogen (AGT),
angiotensin-converting enzyme (ACE) and AT1 receptor (AT1R) were determined in
carotid atheroma plaque, nearby macroscopically intact tissue (MIT), and in ... Cited by 9 - Related articles - All 7 versions
- ►pnas.org K Chalupsky, H Cai - Proceedings of the National Academy of Sciences, 2005 - National Acad Sciences Recent studies demonstrate that oxidative inactivation of tetrahydrobiopterin (H
4 B) may cause uncoupling of endothelial nitric oxide synthase (eNOS) to produce
superoxide ( ). H 4 B was found recyclable from its oxidized form by ... Cited by 83 - Related articles - All 9 versions
P Wenzel, A Daiber, M Oelze, M Brandt, E … - Atherosclerosis, 2008 - Elsevier In male Wistar rats, diabetes was induced by streptozotocin (STZ, 60 mg/kg). In
STZ rats, atorvastatin feeding (20 mg/kg/d, 7 weeks), normalized vascular
dysfunction as analyzed by isometric tension studies, levels of circulating ... Cited by 16 - Related articles - All 31 versions
MC Wendt, A Daiber, AL Kleschyov, A Mülsch, … - Free Radical Biology and Medicine, 2005 - Elsevier The nox2-dependent NADPH oxidase was shown to be a major superoxide source in
vascular disease, including diabetes. Smooth muscle cells of large arteries lack
the phagocytic gp91 phox subunit of the enzyme; however, two homologues ... Cited by 30 - Related articles - All 4 versions
S Cai, J Khoo, S Mussa, NJ Alp, KM Channon - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Impaired nitric oxide (NO) bioactivity and increased
superoxide (SO) production are characteristics of vascular endothelial
dysfunction in dia- betes. The underlying mechanisms remain unknown. In ... Cited by 33 - Related articles - BL Direct - All 5 versions
P Wenzel, E Schulz, M Oelze, J Müller, S … - Free Radical Biology and Medicine, 2008 - Elsevier Several enzymatic sources of reactive oxygen species (ROS) were described as
potential reasons of eNOS uncoupling in diabetes mellitus. In the present study,
we investigated the effects of AT 1 -receptor blockade with chronic ... Cited by 5 - Related articles - All 4 versions
K Shinozaki, Y Nishio, K Ayajiki, Y Yoshida, … - Journal of cardiovascular pharmacology, 2007 - journals.lww.com From the *Departments of Pharmacology; †Department of Medicine, Shiga
University of Medical Science, Otsu, Japan; and ‡Laboratory of Biochemistry,
Faculty of Horticulture, Chiba University, Matsudo, Japan. Cited by 5 - Related articles - BL Direct - All 8 versions
