- ►diabetesjournals.org RC Vasavada, I Cozar-Castellano, D Sipula, AF … - Diabetes, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D-cyclins, cdk-4, p18, p21, p27) are critical
for normal regulation of β-cell proliferation, mass, and function. The retinoblastoma protein,
pRb, is positioned at the very end of a cascade of these regulatory proteins and is ... Cited by 12 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org I Cozar-Castellano, M Haught, AF Stewart - Diabetes, 2006 - Am Diabetes Assoc The rate of pancreatic β-cell replication is extremely slow. For example, Finegood et al. (1) report
that 3% of rodent β-cells replicate every 24 h. Kushner and colleagues (2) have recently reported
that in older mice, this rate is even slower, in the range of 0.07% of β-cells per 24 h. Butler ... Cited by 11 - Related articles - BL Direct - All 5 versions
- ►shouxi.net RC Vasavada, I Cozar-Castellano, D Sipula, AF … - proteins, 2007 - Am Diabetes Assoc Animal studies show that G 1/S regulatory molecules (D- cyclins, cdk-4, p18, p21, p27) are critical
for normal regu- lation of -cell proliferation, mass, and function. The retinoblastoma protein,
pRb, is positioned at the very end of a cascade of these regulatory proteins and is ... Cited by 2 - Related articles - All 2 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA Bigatel, … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by the ß-cells of
the pancreatic islet. Accordingly, strategies that lead to increased pancreatic ß-cell mass, as
well as retained or enhanced function of islets, would be desirable for the treatment of ... Cited by 54 - Related articles - BL Direct - All 5 versions
X Zhang, JP Gaspard, Y Mizukami, J Li, F Graeme- … - Diabetes, 2005 - Am Diabetes Assoc Cyclin D1 can stimulate proliferation by driving cells from the G1 into the S-phase of the mammalian
cell cycle. Previous animal studies have implicated the G1-S transition as a key regulatory checkpoint
governing the proliferation of pancreatic islet cells. We expressed cyclin D1 in the β-cells ... Cited by 32 - Related articles - All 5 versions
I Cozar-Castellano, M Weinstock, M Haught… - Diabetes, 2006 - ncbi.nlm.nih.gov We hypothesized that combined transgenic overexpression of hepatocyte growth factor
(HGF) and placental lactogen in islets would lead to even greater increases in beta-cell mass
and replication than either growth factor alone. This did not occur, suggesting that ... Cited by 22 - Related articles - BL Direct - All 2 versions
- ►tokushima-u.ac.jp [PDF] M Moritani, S Yamasaki, M Kagami, T Suzuki, T … - Molecular and cellular …, 2005 - Elsevier We generated the homozygous transgenic mice with expression of the active form of TGF-β1
by the glucagon promoter (homozygous NOD-TGF-β1). The homozygous NOD-TGF-β1 showed
severe diabetes in 84.6%, impaired glucose tolerance, and low serum insulin levels. The ... Cited by 17 - Related articles - All 4 versions
A Rafacho, VAG Giozzet, AC Boschero, JR Bosqueiro - Pancreas, 2008 - journals.lww.com From the *Department of Physiology and Biophysics, Institute of Biology, State University of Campinas
(UNICAMP), Campinas; and †Department of Physical Education, Faculty of Sciences, São Paulo
State University (UNESP), Bauru, SP, Brazil. ... This study is part of the PhD of A. Rafacho ... Cited by 4 - Related articles - BL Direct - All 3 versions
C Hinault, J Hu, BF Maier, RG Mirmira, RN … - Diabetes Obes …, 2008 - interscience.wiley.com One of the major challenges for developmental biologists and investigators in the field of diabetes
over the last few decades has been to dissect the origin of pancreatic endocrine cells and to
accurately understand the mechanisms that regulate islet cell regeneration. While ... Cited by 3 - Related articles - All 2 versions
[CITATION] Loss of cyclin-dependent kinase (Cdk4) expression causes insulin-deficient …
