RA Ritzel, JJ Meier, CY Lin, JD Veldhuis, PC … - Diabetes, 2007 - Am Diabetes Assoc Insulin secretion from the 2,000–3,000 β-cells in an islet is a highly
synchronized activity with discharge of insulin in coordinate secretory bursts
at approximately 4-min intervals. Insulin secretion progressively declines ... Cited by 28 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org CY Lin, T Gurlo, R Kayed, AE Butler, L … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Islets in type 2 diabetes are characterized by a deficit in
β-cells, increased β-cell apoptosis, and islet amyloid derived from islet
amyloid polypeptide (IAPP). The toxic form of amyloidogenic protein ... Cited by 23 - Related articles - BL Direct - All 5 versions
P Westermark, A Andersson, GT Westermark - Current Diabetes Reports, 2005 - Springer Introduction Protein misfolding and aggregation has increasingly come into focus
as an important disease mechanism. Amyloid constitutes one big group within
protein aggregation and is characterized by formation of fibrils in which ... Cited by 5 - Related articles - BL Direct - All 2 versions
B Konarkowska, JF Aitken, J Kistler, S Zhang … - FEBS J, 2006 - interscience.wiley.com Human amylin is a small fibrillogenic protein that is the major constituent of
pancreatic islet amyloid, which occurs in most subjects with type 2 diabetes.
There is evidence that it can elicit in vitro apoptosis in islet β-cells, ... Cited by 34 - Related articles - BL Direct - All 4 versions
JJW Wiltzius, SA Sievers, MR Sawaya, D … - Protein Science: A Publication of the Protein Society, 2008 - pubmedcentral.nih.gov Islet amyloid polypeptide (IAPP, also called amylin) is associated with type II
diabetes, a disease that has increased over the past two decades and now
afflicts an estimated 20 million people in America and 100 million ... Cited by 16 - Related articles - All 6 versions
- ►jbc.org M Apostolidou, SA Jayasinghe, R Langen - Journal of Biological Chemistry, 2008 - ASBMB Human islet amyloid polypeptide (hIAPP) misfolding is thought to play an
important role in the pathogenesis of type II diabetes mellitus. It has recently
been shown that membranes can catalyze the misfolding of hIAPP via an ... Cited by 11 - Related articles - All 4 versions
- ►diabetesjournals.org JM Lin, ME Fabregat, R Gomis, P Bergsten - Diabetes, 2002 - Am Diabetes Assoc Plasma insulin in healthy subjects shows regular oscillations, which are
important for the hypoglycemic action of the hormone. In individuals with type 2
diabetes, these regular variations are altered, which has been implicated ... Cited by 24 - Related articles - BL Direct - All 5 versions
- ►diabetesjournals.org S Zhang, H Liu, H Yu, GJS Cooper - Diabetes, 2008 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS— We measured responses to hA in isolated mouse
islets and two insulinoma cell lines, wherein we measured Fas/Fas ligand (FasL)
and Fas-associated death domain (FADD) expression by quantitative RT-PCR, ... Cited by 5 - Related articles - BL Direct - All 3 versions
- ►pnas.org AM Ruschak, AD Miranker - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences A central component of a number of degenerative diseases is the deposition of
protein as amyloid fibers. Self-assembly of amyloid occurs by a
nucleation-dependent mechanism that gives rise to a characteristic ... Cited by 18 - Related articles - BL Direct - All 10 versions
- ►shouxi.net C Huang, C Lin, L Haataja, T Gurlo, AE Butler … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Endoplasmic reticulum (ER) stress–induced apoptosis may be a
common cause of cell attrition in diseases characterized by misfolding and
oligomerisation of amyloidogenic proteins. The islet in type 2 diabetes is ... Cited by 56 - Related articles - BL Direct - All 5 versions
