- ►diabetesjournals.org S Boudina, S Sena, H Theobald, X Sheng, JJ … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—db/db hearts exhibited reduced cardiac function and increased MVo 2 .
Mitochondrial reactive oxygen species (ROS) generation and lipid and protein
peroxidation products were increased. Mitochondrial proliferation was ... Cited by 42 - Related articles - BL Direct - All 4 versions
- ►ahajournals.org S Boudina, S Sena, BT O'Neill, P Tathireddy, … - Circulation, 2005 - Am Heart Assoc Methods and Results— Cardiac function, M O 2 , mitochondrial respiration, and
ATP synthesis were measured in 9-week-old ob/ob and control mouse hearts.
Contractile function and M O 2 in glucose-perfused ob/ob hearts were ... Cited by 76 - Related articles - All 10 versions
- ►physiology.org S Boudina, ED Abel - Physiology, 2006 - Am Physiological Soc Diabetes is a worldwide epidemic (112). Cardiovascular disease remains the major
cause of morbidity and mortality in people with diabetes. Epidemiological
studies suggest that the prevalence of heart failure exceeds that which can ... Cited by 39 - Related articles - BL Direct - All 5 versions
S Boudina, S Sena, H Theobald, X Sheng, JJ … - Diabetes, 2007 - Am Diabetes Assoc Page 1. Mitochondrial Energetics in the Heart in Obesity-Related Diabetes
Direct Evidence for Increased Uncoupled Respiration and ... Related articles
H Bugger, S Boudina, XX Hu, J Tuinei, VG … - Diabetes, 2008 - Am Diabetes Assoc RESULTS— Resting cardiac function was normal in Akita mice, and myocardial
insulin sensitivity was preserved. Although Akita hearts oxidized more fatty
acids, myocardial O 2 consumption was not increased, and cardiac efficiency ... Cited by 9 - Related articles - All 4 versions
- ►ahajournals.org JG Duncan, JL Fong, DM Medeiros, BN Finck, … - Circulation, 2007 - Am Heart Assoc Methods and Results— Morphometric analyses demonstrated that cardiac myocyte
mitochondrial volume density was increased in insulin-resistant uncoupling
protein-diptheria toxin A (UCP-DTA) transgenic mice, a murine model of ... Cited by 42 - Related articles - All 4 versions
- ►physiology.org P Yue, T Arai, M Terashima, AY Sheikh, F … - American Journal of Physiology- Heart and Circulatory …, 2007 - Am Physiological Soc The db/db mouse is a well-established model of diabetes. Previous reports have
documented contractile dysfunction (ie, cardiomyopathy) in these animals,
although the extant literature provides limited insights into cardiac ... Cited by 20 - Related articles - BL Direct - All 4 versions
- ►endojournals.org J Buchanan, PK Mazumder, P Hu, G … - Endocrinology, 2005 - Endocrine Soc Hyperglycemia is associated with altered myocardial substrate use, a condition
that has been hypothesized to contribute to impaired cardiac performance. The
goals of this study were to determine whether changes in cardiac ... Cited by 69 - Related articles - BL Direct - All 5 versions
ED Abel, SE Litwin, G Sweeney - Physiological Reviews, 2008 - Am Physiological Soc The dramatic increase in the prevalence of obesity and its strong association
with cardiovascular disease have resulted in unprecedented interest in
understanding the effects of obesity on the cardiovascular system. A ... Cited by 25 - Related articles - BL Direct - All 3 versions
AP McQueen, D Zhang, P Hu, LA Swenson, Y … - Journal of molecular and cellular cardiology, 2005 - Elsevier Diabetics have worse outcomes than nondiabetics after a variety of cardiac
insults. We tested the hypothesis that impaired insulin receptor signaling in
myocytes worsens cardiac remodeling and function following injury, even in ... Cited by 17 - Related articles - All 9 versions
