- ►diabetesjournals.org T Jiang, XX Wang, P Scherzer, P Wilson, J Tallman, H … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Recent studies indicate an important role for nuclear receptors in regulating lipid
and carbohydrate metabolism, fibrosis, and inflammation. Farnesoid X receptor (FXR) is a member
of the nuclear hormone receptor superfamily. FXR is highly expressed in the liver, ... Cited by 18 - Related articles - BL Direct - All 3 versions
S Schinner, R Kratzner, D Baun… - Br J Pharmacol, 2009 - interscience.wiley.com Background and purpose: The transcription factor peroxisome proliferator-activated receptor
γ (PPARγ) is essential for glucose homeostasis. PPARγ ligands reducing insulin levels in vivo
are used as drugs to treat type 2 diabetes mellitus. Genes regulated by PPARγ have been ... Cited by 5 - Related articles - All 3 versions
Q Wang, L Jiang, J Wang, S Li, Y Yu, J You, R Zeng … - Hepatology, 2007 - interscience.wiley.com Hepatic steatosis is a hallmark of non-alcoholic fatty liver disease (NAFLD) and a key component
of obesity-associated metabolic dysfunctions featuring dyslipidemia, insulin resistance and loss
of glycemic control. It has yet to be completely understood how much dysregulated de ... Cited by 6 - Related articles - All 2 versions
RS Ahima - Gastroenterology, 2008 - Elsevier NAFLD was first described in children in the 1980s. 3 As in adults, pediatric NAFLD is associated
with obesity and insulin resistance. [3] and [4] In the United States National Health and Nutrition
Examination Survey (1999–2004), the prevalence of elevated ALT levels (>30 U/l) was ... Cited by 5 - Related articles - All 36 versions
F Marra, S Pastacaldi - Recenti progressi in medicina, 2002 - ncbi.nlm.nih.gov PPAR-gamma belongs to the nuclear hormone receptor superfamily and its ligands include antidiabetic
drugs of the thiazolidindione class, and endogenous molecules, including eicosanoids and fatty
acids. PPAR-gamma is involved in the pathophysiology of obesity and type II diabetes. ... Cited by 5 - Related articles
P Martinez-Fernandez, L Hierro, P Jara, L … - American Journal of …, 2009 - Am Physiological Soc Farnesoid X receptor (FXR) is a bile acid-sensing nuclear receptor that controls bile acid
homeostasis. It has been suggested that downregulation of FXR contributes to the pathogenesis
of an inherited disorder of bile secretion caused by mutations in ATP8B1. We have ... Cited by 6 - Related articles - All 2 versions
J Christopher Corton - Critical Reviews in Toxicology, 2008 - informahealthcare.com Trichloroethylene (TCE) is an industrial solvent and a widespread environmental
contaminant. Induction of liver cancer in mice by TCE is thought to be mediated by two
metabolites, dichloroacetate (DCA) and trichloroacetate (TCA), both of which are ... Cited by 6 - Related articles - All 7 versions
J Sutinen - PPAR Res, 2009 - hindawi.com Highly active antiretroviral therapy (HAART)-associated metabolic complications include lipoatrophy
(loss of subcutaneous adipose tissue (SAT)) and insulin resistance. Thiazolidinediones are
insulin-sensitizing antidiabetic agents which—as an untoward side effect in obese ... Cited by 6 - Related articles - Cached - All 9 versions
X Buqué, P Aspichueta, B Ochoa - Revista Española de Enfermedades …, 2008 - grupoaran.com Page 1. Molecular basis of obesity-related hepatic steatosis X. Buqué, P. Aspichueta
and B. Ochoa Physiology Department. Medicine and Odontology School. Universidad
del País Vasco. Leioa. Bilbao, Spain 1130-0108/2008 ... Cited by 6 - Related articles - View as HTML - All 5 versions
F Marra - British Medical Journal, 2008 - gut.bmj.com Inflammation is an aspect of NASH that has received considerable attention as a possible target
for therapy. Together with hepatocyte damage and fibrosis, inflammation is a marker of the progression
from simple steatosis to steatohepatitis, and is greatly involved in the generation of ... Cited by 6 - Related articles - BL Direct - All 3 versions
