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Scholar Results 1 - 10 of about 101 related to Jarchum: In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A* 0201 transgenic NOD mice. (0.17 sec) 

In vivo cytotoxicity of insulin-specific CD8+ T-cells in HLA-A* 0201 transgenic NOD mice

- diabetesjournals.org
I Jarchum, JC Baker, T Yamada, T Takaki, MP … - Diabetes, 2007 - Am Diabetes Assoc
RESULTS—We found that HLA-A*0201-restricted T-cells isolated from the islets
of the transgenic mice were specific for Ins1 L3–11, Ins1 B5–14, and Ins1/2
A2–10. Insulin-reactive T-cells were present in the islets of mice as ...
Cited by 10 - Related articles - BL Direct - All 4 versions

Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting …

- jimmunol.org
P Blancou, R Mallone, E Martinuzzi, S Severe … - The Journal of Immunology, 2007 - Am Assoc Immnol
Type 1 diabetes (T1D) results from the autoimmune destruction of pancreatic
cells. CD8 + T cells have recently been assigned a major role in cell injury.
Consequently, the identification of autoreactive CD8 + T cells in humans ...
Cited by 10 - Related articles - All 6 versions

HLA-A* 0201-restricted T cells from humanized NOD mice recognize autoantigens of potential …

- jimmunol.org
T Takaki, MP Marron, CE Mathews, ST … - The Journal of Immunology, 2006 - Am Assoc Immnol
In both humans and NOD mice, particular MHC genes are primary contributors to
development of the autoreactive CD4 + and CD8 + T cell responses against
pancreatic cells that cause type 1 diabetes (T1D). Association studies have ...
Cited by 34 - Related articles - BL Direct - All 5 versions

Equivalent Specificity of Peripheral Blood and Islet-Infiltrating CD8+ T Lymphocytes in …

- jimmunol.org
E Enee, E Martinuzzi, P Blancou, JM Bach, R … - The Journal of Immunology, 2008 - Am Assoc Immnol
CD8 + T cells play an important role in the initiation of insulitis and in the
destructive stage leading to insulin-dependent diabetes mellitus. A string of
recent studies has led to the identification of numerous HLA-A2-restricted ...
Cited by 2 - Related articles - All 3 versions

[CITATION] Anti-glucagon insulitis and A-cell hyperplasia of pancreatic islets.


U Fuchs, HH von Dorsche, M Ziegler, H … - Zeitschrift für mikroskopisch-anatomische Forschung, 1988 - ncbi.nlm.nih.gov
1: Z Mikrosk Anat Forsch. 1988;102(5):829-32. Anti-glucagon insulitis
and A-cell hyperplasia of pancreatic islets. Fuchs U, von ...
Cited by 2 - Related articles - All 2 versions

[CITATION] Anti-glucagon antibodies in diabetes mellitus.


A Gergely, L Korányl, T Halmos, M Zsombok, F … - Annales immunologiae Hungaricae, 1973 - ncbi.nlm.nih.gov
1: Ann Immunol Hung. 1973;17:231-3. Anti-glucagon antibodies in diabetes
mellitus. Gergely A, Korányl L, Halmos T, Zsombók M, Péterfy ...
Cited by 3 - Related articles

CD8+ T-cell responses identify β-cell autoimmunity in human type 1 diabetes

- diabetesjournals.org
R Mallone, E Martinuzzi, P Blancou, G Novelli … - Diabetes, 2007 - Am Diabetes Assoc
Despite the understanding that type 1 diabetes pathogenesis is mediated by
T-cells, detection of these rare lymphocytes remains largely elusive. Suitable
T-cell assays are highly needed, since they could offer preclinical ...
Cited by 31 - Related articles - BL Direct - All 6 versions

[CITATION] Molecular complementarity III. Molecular complementarity as the basis for peptide hormone …


RS Root-Bernstein - J. Theor. Biol, 2002
Cited by 4 - Related articles

A shared TCR CDR3 sequence in NOD mouse autoimmune diabetes

- oxfordjournals.org
Y Tikochinski, D Elias, C Steeg, H Marcus, M … - International immunology, 1999 - Jpn Soc Immunol
T cells involved in autoimmune diseases have been characterized by the genetic
elements used to construct their autoimmune TCR. In the present study, we
sequenced the and ß chains of the TCR expressed by a CD4 + T cell clone, ...
Cited by 4 - Related articles - BL Direct - All 8 versions

Early autoimmune destruction of islet grafts is associated with a restricted repertoire of …

- jimmunol.org
CP Wong, L Li, JA Frelinger, R Tisch - The Journal of Immunology, 2006 - Am Assoc Immnol
Type 1 diabetes (T1D) 3 is an organ-specific autoimmune disease characterized by
the destruction of the insulin-producing pancreatic cells. The nonobese diabetic
(NOD) mouse spontaneously develops T cell-dependent cell destruction (1, 2, ...
Cited by 18 - Related articles - BL Direct - All 4 versions


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