- ►shouxi.net EP Kwan, L Xie, L Sheu, T Ohtsuka, HY Gaisano - Diabetes, 2007 - Am Diabetes Assoc RESULTS—To determine which exocytotic steps caused by Munc13-1 deficiency are rescued
by Epac2 and PKA, we used patch-clamp capacitance measurements, showing that 1) cAMP
restored the reduced readily releasable pool (RRP) and partially restored refilling of a ... Cited by 16 - Related articles - BL Direct - All 4 versions
A Tomas, P Meda, R Regazzi, JE Pessin, PA Halban - Traffic, 2008 - interscience.wiley.com Munc 18-1 is a member of the Sec/Munc family of syntaxin-binding proteins known to bind to
the plasma membrane Q-SNARE syntaxin1 and whose precise role in regulated exocytosis remains
controversial. Here, we show that Munc 18-1 plays a positive role in regulated insulin ... Cited by 9 - Related articles - BL Direct - All 4 versions
H Hatakeyama, N Takahashi, T Kishimoto, T … - The Journal of …, 2007 - Physiological Soc It has been reported that cAMP regulates Ca 2 + -dependent exocytosis via protein kinase A
(PKA) and exchange proteins directly activated by cAMP (Epac) in neurons and secretory
cells. It has, however, never been clarified how regulation of Ca 2 + -dependent ... Cited by 15 - Related articles - BL Direct - All 9 versions
- ►jbc.org SM Harper, H Wienk, RW Wechselberger, JL Bos, … - Journal of Biological …, 2008 - ASBMB Epac1 is a cAMP-responsive exchange factor for the small G-protein Rap. It consists of a regulatory
region containing a cyclic nucleotide binding (CNB) domain and a catalytic region that activates
Rap. In the absence of cAMP, access of Rap to the catalytic site is blocked by the ... Cited by 3 - Related articles - All 8 versions
- ►cell.com L Kang, Z He, P Xu, J Fan, A Betz, N Brose, T Xu - Cell Metabolism, 2006 - Elsevier Munc13-1 is a presynaptic protein that is essential for synaptic vesicle priming. Deletion of
Munc13-1/unc13 causes total arrest of synaptic transmission due to a complete loss of
fusion-competent synaptic vesicles. The requirement of Munc13-1 for large dense-core ... Cited by 23 - Related articles - All 13 versions
EP Kwan, HY Gaisano - Diabetes Obes Metab, 2007 - interscience.wiley.com Exocytosis of insulin vesicles in the pancreatic β-cell involves a sequence of regulated
events, whose normal function and efficient adaptation to increased demand are essential for
the maintenance of glucose homeostasis. These exocytotic events comprise the ... Cited by 4 - Related articles - All 2 versions
L Balasubramanian, JSK Sham, KP Yip - Pflügers Archiv European Journal of …, 2008 - Springer Abstract It has been the general consensus that cAMP- mediated PKA-dependent phosphorylation
of aquaporin-2 is the primary mechanism of vasopressin to regulate osmotic water permeability
in kidney collecting duct. By using laser scanning confocal microscopy to monitor [Ca2+]i ... Cited by 4 - Related articles - BL Direct - All 3 versions
- ►nih.gov GG Holz, OG Chepurny, F Schwede - Cellular signalling, 2008 - Elsevier The identification of 2′-O-methyl substituted adenosine-3′,5′-cyclic monophosphate
(cAMP) analogs that activate the Epac family of cAMP-regulated guanine nucleotide exchange
factors (cAMP-GEFs, also known as Epac1 and Epac2), has ushered in a new era of ... Cited by 32 - Related articles - All 4 versions
- ►diabetesjournals.org EP Kwan, L Xie, L Sheu, CJ Nolan, M Prentki, A Betz, N … - Diabetes, 2006 - Am Diabetes Assoc Munc13-1 is a diacylglycerol (DAG) receptor that is essential for synaptic vesicle priming. We
recently showed that Munc13-1 is expressed in rodent and human islet β-cells and that its levels
are reduced in islets of type 2 diabetic humans and rat models, suggesting that Munc13-1 ... Cited by 21 - Related articles - All 5 versions
- ►diabetesjournals.org W Zhang, L Lilja, SA Mandic, J Gromada, K Smidt, J … - Diabetes, 2006 - Am Diabetes Assoc Tomosyn, a syntaxin-binding protein, is capable of dissociating mammalian homolog of the Caenorhabditis
elegans unc-18 gene from syntaxin and is involved in the regulation of exocytosis. We have investigated
the expression, cellular localization, and functional role of tomosyn in pancreatic ß-cells. ... Cited by 15 - Related articles - BL Direct - All 5 versions
