- ►diabetesjournals.org S Lee… - Diabetes, 2007 - Am Diabetes Assoc RESULTS—In vitro functional studies of the resultant mutant receptors revealed
impaired signaling activity but normal ligand binding and cell surface
expression. The heterozygotes demonstrated higher leptin levels and ... Cited by 11 - Related articles - BL Direct - All 4 versions
- ►auburn.edu [PDF] YX Tao - BBA-Molecular Basis of Disease, 2007 - Elsevier It is controversial whether mutation in the melancortin-3 receptor (MC3R) gene
is a cause for monogenic obesity in humans. Three novel mutations in the MC3R,
A293T, I335S, and X361S, were identified from morbidly obese subjects. We ... Cited by 4 - Related articles - All 7 versions
- ►endojournals.org J Rutanen, J Pihlajamaki, M Vanttinen, U … - Journal of Clinical Endocrinology & Metabolism, 2007 - Endocrine Soc Context: The melanocortin-3 receptor (MC3R) is a part of the melanocortin system
that regulates appetite and energy metabolism. The Lys/Thr6 and Ile/Val81
polymorphisms of the MC3R gene have been previously associated with high ... Cited by 3 - Related articles - BL Direct - All 3 versions
M Chen, CJ Aprahamian, A Celik, KE … - Biochemistry, 2006 - pubs.acs.org Melanocortin-3 receptor (MC3R), primarily expressed in the hypothalamus, plays
an important role in the regulation of energy homeostasis. MC3R-deficient (MC3R
- / - ) mice demonstrate increased fat mass, higher feeding efficiency, ... Cited by 8 - Related articles - All 4 versions
- ►endojournals.org YX Tao, DL Segaloff - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Although melanocortin-4 receptor mutations are the cause of the most common
monogenic form of obesity, the involvement of the melanocortin-3 receptor (MC3R)
in the pathogenesis of obesity is unknown. Earlier studies failed to ... Cited by 25 - Related articles - BL Direct - All 8 versions
- ►nih.gov [PDF] N Feng, SF Young, G Aguilera, E Puricelli, … - Diabetes, 2005 - Am Diabetes Assoc Both human linkage studies and MC3R knockout mouse models suggest that the MC3R
may play an important role in energy homeostasis. Here we show that among 355
overweight and nonoverweight children, 8.2% were double homozygous for a ... Cited by 30 - Related articles - BL Direct - All 7 versions
M Rached, A Buronfosse, M Begeot, A … - BBA-Molecular Basis of Disease, 2004 - Elsevier Melanocortins are known to be involved in the regulation of feeding behavior.
These hormones mediate their effects through G protein-coupled receptors (GPCRs)
by stimulating adenylate cyclase. The melanocortin 3 receptor (MC3R) in the ... Cited by 18 - Related articles - All 3 versions
- ►endojournals.org EH Hani, S Dupont, E Durand, C Dina, S … - Journal of Clinical Endocrinology & Metabolism, 2001 - Endocrine Soc Familial genetic studies of type 2 diabetes (T2DM) of different human
populations, including the French Caucasians, suggested evidence for linkage of
T2DM and human chromosome 20q13, a region where maps the melanocortin 3 ... Cited by 29 - Related articles - All 5 versions
J Wong, DR Love, C Kyle, A Daniels, M White … - Diabetes research and clinical practice, 2002 - Elsevier Genetic studies suggest a diabetes susceptibility locus on human chromosome 20,
near the melanocortin receptor-3 (MC3-R) gene. We examined the MC3-R as a
candidate gene for type 2 diabetes in 12 members of a large Maori kindred ... Cited by 16 - Related articles - All 11 versions
- ►nih.gov SX Wang, ZC Fan, YX Tao - biochemical pharmacology, 2008 - Elsevier The melanocortin-3 receptor (MC3R) is an important regulator of energy
homeostasis, inflammation, and cardiovascular function. Inactivating mutations
in MC3R gene are associated with childhood obesity. How MC3R binds to its ... Cited by 4 - Related articles - All 7 versions
