- ►shouxi.net RD Wideman, SD Covey, GC Webb, DJ Drucker, TJ … - Diabetes, 2007 - Am Diabetes Assoc OBJECTIVE—Glucagon, which raises blood glucose levels by stimulating hepatic glucose
production, is produced in α-cells via cleavage of proglucagon by prohormone convertase
(PC)-2. In the enteroendocrine L-cell, proglucagon is differentially processed by the ... Cited by 5 - Related articles - BL Direct - All 5 versions
RD Wideman, SL Gray, SD Covey, GC Webb, TJ Kieffer - 2008 - nature.com Type 2 diabetes (T2D) is characterized by elevated blood glucose levels owing to insufficient
secretion and/or activity of the glucose-lowering hormone insulin. Glucagon-like peptide-1
(GLP-1) has received much attention as a new treatment for diabetes because of its ... Cited by 1 - Related articles - All 4 versions
- ►endocrinology-journals.org T Jin - Journal of Endocrinology, 2008 - Soc Endocrinology The proglucagon gene (gcg) encodes a number of peptide hormones that are of cell-type specifically
expressed in the pancreatic islets, the distal ileum and the large intestine, as well as certain brain
neuronal cells. These hormones are important in controlling blood glucose homeostasis, ... Cited by 3 - Related articles - All 8 versions
- ►diabetesjournals.org [PDF] RD Wideman, SD Covey, GC Webb, DJ Drucker, TJ … - Diabetes, 2007 - Am Diabetes Assoc Running Title: Transplantation of PC2- or PC1/3-expressing α-cells ... 2350 Health Sciences
Mall, Vancouver, British Columbia, V6T 1Z3 Email: tim.kieffer@ubc.ca ... Received for publication
23 April 2007 and accepted in revised form 6 August 2007. ... 1 Laboratory of Molecular ... Cited by 2 - Related articles - All 2 versions
TJ Kieffer, TJ Kieffer - Am Diabetes Assoc Running Title: Transplantation of PC2- or PC1/3-expressing α-cells ... 2350 Health Sciences
Mall, Vancouver, British Columbia, V6T 1Z3 Email: tim.kieffer@ubc.ca ... Received for publication
23 April 2007 and accepted in revised form 6 August 2007. ... 1 Laboratory of Molecular ... Related articles
RD Wideman, ILY Yu, TD Webber, CB … - Proceedings of the …, 2006 - National Acad Sciences Glucagon-like peptide 1 (GLP-1) is a hormone that has received significant attention as a therapy
for diabetes because of its ability to stimulate insulin biosynthesis and release and to promote
growth and survival of insulin-producing β cells. While GLP-1 is produced from the ... Cited by 21 - Related articles - BL Direct - All 10 versions
- ►physiology.org Y Fujita, JWY Chui, DS King, T Zhang, J … - American Journal of …, 2008 - Am Physiological Soc Glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) are
incretin hormones that play important roles in maintaining glucose homeostasis and are being
actively pursued as novel therapeutic agents for diabetes. GIP is produced by dispersed ... Cited by 5 - Related articles - All 4 versions
RD Wideman, TJ Kieffer - Trends in Endocrinology & Metabolism, 2009 - Elsevier The incretin hormones, glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like
peptide-1 (GLP-1), are produced predominantly by enteroendocrine cells and have multiple
blood glucose-lowering effects. Recent years have seen a surge of interest in ... Related articles - All 3 versions
- ►nih.gov LS Katz, Y Gosmain, E Marthinet, J … - Molecular and Cellular …, 2009 - Am Soc Microbiol Pax6 is important in the development of the pancreas and was previously shown to regulate
pancreatic endocrine differentiation, as well as the insulin, glucagon, and somatostatin
genes. Prohormone convertase 2 (PC2) is the main processing enzyme in pancreatic ... Related articles - All 4 versions
- ►endojournals.org E Goncz, MZ Strowski, C Grotzinger, KW Nowak, P … - Endocrinology, 2008 - Endocrine Soc Orexin-A (OXA) regulates food intake and energy homeostasis. It increases insulin secretion
in vivo and in vitro, although controversial effects of OXA on plasma glucagon are reported. We
characterized the effects of OXA on glucagon secretion and identify intracellular target ... Cited by 7 - Related articles - BL Direct - All 4 versions
