J Westerbacka, M Kolak, T Kiviluoto, P Arkkila, J Sirén, … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—The following genes were significantly upregulated in NAFL: peroxisome
proliferator–activated receptor (PPAR)γ2 (2.8-fold), the monocyte-attracting chemokine CCL2
(monocyte chemoattractant protein [MCP]-1, 1.8-fold), and four genes associated with ... Cited by 24 - Related articles - BL Direct - All 3 versions
- ►physiology.org D Greco, A Kotronen, J Westerbacka, O … - American Journal of …, 2008 - Am Physiological Soc Despite the high prevalence of nonalcoholic fatty liver disease (NAFLD), little is known of its pathogenesis
based on study of human liver samples. By the use of Affymetrix GeneChips (17,601 genes),
we investigated gene expression in the human liver of subjects with extreme steatosis ... Cited by 17 - Related articles - BL Direct - All 5 versions
DG Mashek, LO Li, RA Coleman - Future Lipidol., 2007 - Future Medicine Thirteen homologous proteins comprise the long-chain acyl-CoA synthetase (ACSL), fatty acid
transport protein (FATP), and bubblegum (ACSBG) subfamilies that activate long-chain and
very-long-chain fatty acids to form acyl-CoAs. Gain- and loss-of-function studies show ... Cited by 6 - Related articles - BL Direct - All 3 versions
H Doege, RA Baillie, AM Ortegon, B Tsang, Q Wu, S … - Gastroenterology, 2006 - Elsevier Background & Aims: Fatty acid transport protein 5 (FATP5/Slc27a5) has been shown to be a
multifunctional protein that in vitro increases both uptake of fluorescently labeled long-chain
fatty acid (LCFA) analogues and bile acid/coenzyme A ligase activity on overexpression. ... Cited by 37 - Related articles - All 16 versions
JM Lavoie, MS Gauthier - Cellular and molecular life sciences, 2006 - Springer Abstract. Hepatic steatosis may develop as a conse- quence of several dysfunctions. An increased
circulating non-esterified fatty acid (NEFA) pool seems to be a ma- jor determinant in the pathogenesis
of non-alcoholic fatty liver disease. Increased activation of the transcription fac- tor sterol- ... Cited by 20 - Related articles - BL Direct - All 5 versions
M Adiels, J Westerbacka, A Soro-Paavonen, AM … - Diabetologia, 2007 - Springer Page 1. ARTICLE Acute suppression of VLDL 1 secretion rate by insulin is associated
with hepatic fat content and insulin resistance M. Adiels & J. Westerbacka & A.
Soro-Paavonen & AM Häkkinen & S. Vehkavaara & MJ Caslake & ... Cited by 21 - Related articles - BL Direct - All 2 versions
F Chiappini, A Barrier, R Saffroy, MC Domart, N … - Laboratory …, 2005 - nature.com Understanding the molecular mechanisms underlying fatty liver disease (FLD) in humans is of
major importance. We used high-density oligonucleotide microarrays (22.3 K) to assess the mechanisms
responsible for the development of human liver steatosis. We compared global gene ... Cited by 27 - Related articles - BL Direct - All 6 versions
N Higuchi, M Kato, Y Shundo, H Tajiri, M Tanaka, … - Hepatol Res, 2008 - interscience.wiley.com Aim: Nonalcoholic fatty liver disease (NAFLD) is one of the most frequent causes of liver dysfunction
and its incidence has increased markedly. However, the mechanisms involved in the pathogenesis
of NAFLD in humans have not been thoroughly investigated. Sterol regulatory element ... Cited by 15 - Related articles - All 3 versions
A Rubio, E Guruceaga, M Vázquez-Chantada, J … - Journal of hepatology, 2007 - Elsevier We identified a gene-pathway associated with NASH, that accurately distinguishes between
patients with early-stage NASH and controls. Patients with steatosis have a gene expression
pattern intermediate between that of NASH and controls. Promoter analysis revealed that ... Cited by 15 - Related articles - All 13 versions
S Ito, T Yukawa, S Uetake, M Yamauchi - Alcohol Clin Exp Res, 2007 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 4 - Related articles - BL Direct - All 4 versions
