- ►diabetesjournals.org AI Oprescu, G Bikopoulos, A Naassan, EM Allister, C … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Forty-eight–hour infusion of oleate decreased the insulin and C-peptide responses
to a hyperglycemic clamp (P < 0.01), an effect prevented by coinfusion of the antioxidants N-acetylcysteine
(NAC) and taurine. Similar to the findings in vivo, 48-h infusion of oleate decreased ... Cited by 21 - Related articles - BL Direct - All 3 versions
C Xiao, A Giacca, GF Lewis - Diabetologia, 2008 - Springer Page 1. ARTICLE Oral taurine but not N-acetylcysteine ameliorates NEFA-induced
impairment in insulin sensitivity and beta cell function in obese and overweight,
non-diabetic men C. Xiao & A. Giacca & GF Lewis Received ... Cited by 8 - Related articles - BL Direct - All 2 versions
N Leung, T Sakaue, A Carpentier, K Uffelman, A … - Diabetologia, 2004 - Springer Aims/hypothesis. A prolonged increase of plasma NEFA impairs acute glucose-stimulated insulin
secre- tion (GSIS) in vitro and in vivo. Our study therefore examined the combined effect of increased
plasma NEFA and glucose on GSIS in humans. Methods. We examined GSIS on four ... Cited by 16 - Related articles - BL Direct - All 4 versions
- ►endocrinology-journals.org E Diakogiannaki, HJ Welters, NG Morgan - Journal of Endocrinology, 2008 - Soc Endocrinology Exposure of pancreatic β-cells to long-chain fatty acids leads to the activation of some components
of the endoplasmic reticulum (ER) stress pathway and this mechanism may underlie the ability
of certain fatty acids to promote β-cell death. We have studied ER stress in BRIN-BD11 β- ... Cited by 7 - Related articles - BL Direct - All 4 versions
- ►physiology.org E Lai, G Bikopoulos, MB Wheeler, M … - American Journal of …, 2008 - Am Physiological Soc Chronic exposure to elevated saturated free fatty acid (FFA) levels has been shown to induce
endoplasmic reticulum (ER) stress that may contribute to promoting pancreatic β-cell
apoptosis. Here, we compared the effects of FFAs on apoptosis and ER stress in human ... Cited by 19 - Related articles - BL Direct - All 3 versions
PC Moore, MA Ugas, DK Hagman, SD Parazzoli, V … - Diabetes, 2004 - Am Diabetes Assoc Prolonged exposure to elevated levels of fatty acids adversely affects pancreatic β-cell
function. Here we investigated 1) whether ceramide synthesis, which we reported to mediate
fatty acid inhibition of insulin gene expression, also inhibits insulin secretion and 2) ... Cited by 43 - Related articles - BL Direct - All 7 versions
C Xiao, A Giacca, A Carpentier, GF Lewis - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Prolonged elevation of plas- ma specific fatty acids may exert differential
effects on glucose-stimulated insulin secretion (GSIS), insulin sensi- tivity and clearance. Subjects
and methods: We examined the effect of oral ingestion, at regular intervals for 24 h, of an ... Cited by 23 - Related articles - BL Direct - All 3 versions
- ►endocrinology-journals.org E Diakogiannaki, S Dhayal, CE Childs, PC … - Journal of …, 2007 - Soc Endocrinology Long-chain saturated and monounsaturated fatty acids differ in their propensity to induce ß-cell
death in vitro with palmitate (C16:0) being cytotoxic, whereas palmitoleate (C16:1n-7) is
cytoprotective. We now show that this cytoprotective capacity extends to a poorly ... Cited by 14 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org A Carpentier, B Zinman, N Leung, A Giacca, AJG … - Diabetes, 2003 - Am Diabetes Assoc The Oji-Cree population of the Sandy Lake region of Ontario, Canada, has the third highest prevalence
of type 2 diabetes in the world. Changes in their diet and physical activity over the past
half-century, particularly the marked increase in consumption of dietary fats, are felt to be ... Cited by 15 - Related articles - BL Direct - All 6 versions
DS Luciani, KS Gwiazda, TLB Yang, TB Kalynyak, Y … - Diabetes, 2009 - Am Diabetes Assoc RESULTS—Neither RyR nor IP 3 R inhibition, alone or in combination, caused robust death
within 24 h. In contrast, blocking sarco/endoplasmic reticulum ATPase (SERCA) pumps depleted
ER Ca 2+ and induced marked phosphorylation of PKR-like ER kinase (PERK) and ... Cited by 3 - Related articles - All 3 versions
